全身体积描记系统WBP

文献支持全身体积描记系统WBP

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品牌:塔望科技

货号:WBP

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保修期 :12个月

现货状态 :2周

供应商 :塔望科技

产品描述

气道高反应性(Airway hyperresponsiveness,AHR)、气道炎症和可逆的气道阻塞是支气管哮喘的特征。通过动物模型可研究用于防治气道炎症和AHR的方法和受试药物。传统的方式多采用气管插管,检测气道阻力和肺顺应性来评估动物气道功能的改变。但这些方法有其局限性,如整体试验中麻醉药物的影响,麻醉深浅和麻醉药物对AHR的神经源和气道炎症的影响,实验人员手术操作技术上的要求和耗时,麻醉或手术后动物存活困难不能长期跟踪研究等因素。
无约束全身体积描记法(whole-body plethysmograph,WBP)可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试,避免了创伤性气管切开术及麻醉的影响,在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷,并适合长期跟踪研究。


产品详情
全身体积描记系统(whole-body plethysmograph,WBP)作为无创检测动物肺功能的一种经典方式,避免了麻醉及气管插管测试对动物造成的损伤,可以对2019-nCov、SARS、MERS感染下的动物肺功能指标进行长期跟踪研究。测量指标如潮气量、分钟通气量、呼气峰值流速、吸气峰值流速、呼吸频率、Penh等。这些数据和临床的数据可以建立直接的相关性,适用于新型冠状病毒、SARS‐CoV和MERS等感染研究。

产品特点
适用动物种类:小鼠、幼鼠、大鼠、豚鼠、兔子、犬、猫、小型猪、猴等动物
具有喂食进水装置以方便超长时间的实验
测量通道:1-64通道
自动化偏流控制功能
可配置高频振荡雾化给药系统
特殊的减噪结构设计,可有效减少环境变化造成的干扰
可进行偏流仪降噪,提高信号的信噪比,减少系统噪音
自动校准功能,同对描记器进行全自动标定,减少手工操作引入的误差,提高实验效率
支持外接氮气或其它气体,完成低氧实验
具有分析软件,数据可保存至excel或txt格式


可选择的功能
温湿度检测功能
咳嗽检测功能
自动活动状态静脉注射给药
心电、体温、活动度遥测
同步视频采集和记录
其它功能可定制


检测参数
Ti:吸气时间(s)
Te:呼气时间(s)
PIF:最大吸气流速(ml/s)
PEF:最大呼气流速(ml/s)
Volbal:呼吸比
F:呼吸频率(次/min)
Vt:潮气量(ml)
Mv:分钟通气量(ml)
AV:累积体积(ml)
EF50:呼出50%气量时对应的呼气流速(ml/s)
EIP:吸气峰值压力(仅在侵入式法测量时有效)
EEP:呼气峰值压力(仅在侵入式法测量时有效)
TR:松弛时间
PenH:增强呼气间歇(enhanced pause)


检测参数
 
 







呼吸频率             吸气时间        松弛时间        潮气量          呼吸流量          累积体积
吸气流量峰值      吸气末暂停     Penh             每分通气量    呼气时间
呼气流量峰值      呼气末暂停     每分通气量    其它参数


雾化给药:精确 、定量



 




 
 
相关扩展应用
1、吸入式毒理


将染毒物质 引入动物体积描记器,用于毒理研究                                                     

2、低氧研究  
 










可用于低氧或高氧实验


3、呼吸代谢监控 、嗅觉行为学                                               

监测吸氧浓度、 CO2浓度、呼吸代谢率,以用于嗅觉刺激相关 的行为学实验
 
4、光遗传/EEG/电生理集成








可以和光遗传技术 、EEG、EMG、电生理等技术联用

5、活动跑轮监测联用                                                                       

同步监测动物活动量,可增加呼吸代谢监控功能

6、持续注射给药微透析联用










可实现清醒状态下连续给药、采血、 微透析实验

7、
同步视频监测

同步的视频录像文件

8、咳嗽检测







通过软件自动监测咳嗽事件

9、
各种动物呼吸检测                                                            
 
可定制各种大动物体积描记器, 如兔、 犬、 猴等

10、其它生理指标测量
可在麻醉或清醒状态下测量心电、血压、体温、心率等指标 ,可与植入式遥测设备联合使用;
如果您有特殊的实验需求 ,请联系我们具体商谈。
 
WBP与脑电肌电监测联用
同步监测EEG和EMG波形图、 呼吸信号等,可用于监测动物睡眠状态


选型规格
名称 型号 说明 单位
全身体积描记系统 WBP-4M 四通道,小鼠
全身体积描记系统 WBP-4R 四通道,大鼠
全身体积描记系统 WBP-4MR 四通道,大小鼠通用
全身体积描记系统 WBP-8M 八通道,小鼠
全身体积描记系统 WBP-8R 八通道,大鼠
全身体积描记系统 WBP-8MR 八通道,大小鼠通用
 

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