文献支持SOCS1 Polyclonal Antibody_货号:E-AB-15855_多克隆抗体

Verified Samples in WB:HT29,231
Verified Samples in IHC:Human liver cancer,Human ovarian cancer

WB 1:500-1:2000, IHC 1:100-1:300

Polyclonal

IgG

Synthetic peptide of human SOCS1

SOCS1

CISH 1;CISH1;Cytokine inducible SH2 protein 1;JAB;JAK binding protein;JAK-binding protein;Janus kinase binding protein;SOCS 1;SOCS-1;Socs1;SOCS1;SSI 1;SSI-1;SSI1;STAT induced STAT inhibitor 1;STAT-induced STAT inhibitor 1;Suppressor of cytokine signaling 1;Supressor of cytokine signalling 1;TEC interacting protein 3;Tec-interacting protein 3;TIP 3;TIP-3;TIP3抗体

O15524

24kDa

Cytosol,Nucleus,nucleoplasm,Other locations:cytoplasm,cytoplasmic ribonucleoprotein granule,cytoplasmic vesicle

0.6 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction

Unconjugated

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.