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NSC 228155

CAS No. : 113104-25-9

MCE 国际站：NSC 228155

产品活性：NSC 228155 为 EGFR 激活剂，可与 EGFR 的胞外区域结合，诱导 EGFR 的磷酸化。NSC 228155 是一种有效的 KIX-KID 相互作用抑制剂，能够抑制 CREB 的激酶诱导结构域 (KID) 和 KIX (KID 相互作用结构域，来自 CBP) 的相互作用，IC₅₀ 值为 0.36 μM。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Epigenetics

作用靶点：EGFR  |  Histone Acetyltransferase  |  Epigenetic Reader Domain

In Vitro: NSC 228155 (100 μM) enhances EGFR tyrosine phosphorylation via the action of SOD1.
NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC₅₀s of 2.09 and 6.14 μM, respectively.
NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells.

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