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保存条件 :Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
库存 :货期:1-2天
供应商 :MedChemExpress LLC
CAS号 :1445846-30-9
规格 :10 mM * 1 mL/1 mg/5 mg/10 mg
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GPR84 antagonist 8
CAS No. : 1445846-30-9
MCE 国际站:GPR84 antagonist 8
产品活性:GPR84 antagonist 8 是一种选择性 GPR84 拮抗剂。
研究领域:GPCR/G Protein
作用靶点:GPR84
In Vitro: GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. To test the hypothesis that blocking the activation of GPR84 can be a potential anti-inflammatory strategy in different inflammatory diseases, GPR84 antagonist 8 is used. The potency and specificity of GPR84 antagonist 8 is assessed tusing GPR84-CHO cells in the cAMP assay. GPR84 antagonist 8 effectively inhibits the action of 6-OAU in decreasing cAMP production in GPR84-CHO cells. To test GPR84 antagonist 8’s inhibition of the pro-inflammatory effects of GPR84 activation in macrophages, LPS pre-treated BMDMs are incubated with 10 µM GPR84 antagonist 8 for 30 min before adding 1 µM 6-OAU. Protein analysis by Western Blot shows that the GPR84 antagonist 8 partially blocks the phosphorylation of AKT and ERK induced by 6-OAU.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | GLPG1205 | 6-OAU | Fezagepras sodium | ZQ-16 | GPR84 antagonist 1 | GPR84 antagonist 2 | GPR84 antagonist 3
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