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保存条件 :4°C, sealed storage, away from moisture
库存 :货期:1-2天
供应商 :MedChemExpress LLC
CAS号 :2070015-10-8
规格 :10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
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ML204 hydrochloride
CAS No. : 2070015-10-8
MCE 国际站:ML204 hydrochloride
产品活性:ML204 hydrochloride 是一个有效的、选择性的 TRPC4/TRPC5 通道的抑制剂,较 TRPC6 的选择性高出 20 倍,不影响其他的 TRP 通道和电压门控的钠、钾或 Ca2+ 通道。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:TRP Channel
In Vitro: ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
ML204 hydrochloride blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors.
ML204 hydrochloride blocks LPS-induced TRPC5 channel activity.
In Vivo: ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.
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