糖皮质激素受体多克隆抗体/糖皮质激素受体多克隆抗体

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英文名 ：GR Polyclonal Antibody

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：30μl///100μl///200μl

关键词：GR抗体;糖皮质激素受体抗体;糖皮质激素受体;NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1;ABP54668

中文名称：糖皮质激素受体多克隆抗体/GR Polyclonal Antibody

英文名称：GR Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP54668.pdf

产品描述：兔抗-糖皮质激素受体 多克隆抗体

NR3C1 encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in NR3C1 are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID: 15866175).

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