Cystatin C Mouse 单克隆抗体 (3B12)/Cystatin C Mouse 单克隆抗体 (3B12)

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英文名 ：Cystatin C Mouse Monoclonal Antibody (3B12)

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：100μl

关键词：Cystatin C抗体;Cystatin C Mouse 抗体 ;Cystatin C Mouse ;CST3;ABM0075

中文名称：Cystatin C Mouse 单克隆抗体 (3B12)/Cystatin C Mouse Monoclonal Antibody (3B12)

英文名称：Cystatin C Mouse Monoclonal Antibody (3B12)

产品说明书：http://www.abbkine.cn/datasheet/ABM0075.pdf

产品描述：小鼠抗-Cystatin C 单克隆抗体 (3B12)

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins， type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. CST3 (cystatin C) is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in CST3 has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.

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