ERCC1 单克隆抗体/ERCC1 单克隆抗体

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英文名 ：ERCC1 Monoclonal Antibody

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：100μl

关键词：ERCC1抗体;ERCC1 抗体;ERCC1 ;TNF α 单克隆抗体;ABM0029

中文名称：ERCC1 单克隆抗体/ERCC1 Monoclonal Antibody

英文名称：ERCC1 Monoclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABM0029.pdf

产品描述：小鼠抗-ERCC1单克隆抗体

The product of ERCC1 functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. ERCC excision repair 1, endonuclease non-catalytic subunit forms a heterodimer with the XPF endonuclease (also known as ERCC4， and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in ERCC1 result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of ERCC1 may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for ERCC1. The last exon of ERCC1 overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

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