Anti-SENP6 antibody

供应商 ：上海机纯实业有限公司

库存 ：大量

克隆性 ：多克隆

保质期 ：12个月

抗体英文名 ：Anti-SENP6 antibody

宿主 ：Rabbit

适应物种 ：人/动物/植物

应用范围 ：ELISA, WB

浓度 ：1.14 mg/ml

保存条件 ：-20°C

规格 ：25 μl/100 μl/200 μl

Anti-SENP6 antibody

Cat. No.     JC261322  
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-SENP6 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Synthetic peptide of human SENP6
Reactivity                 Human
Content                     1.14 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 SENP6
Full name                 SUMO1/sentrin specific peptidase 6
Synonyms    SSP1; SUSP1
Swissprot    Q9GZR1

Target Background
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Anti-SENP6 antibody
Applications
Western blotting
Predicted band size:126 kDa
Positive control:Human prostate tissue lysate 
Recommended dilution: 500-2000