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靶点 :MCL1
浓度 :1 mg/mL.
应用范围 :ICC,IHC-P
宿主 :Rabbit
适应物种 :Human, Mouse
保质期 :1年
供应商 :Huabio
标记物 :Non-conjugated
保存条件 :Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
形态 :Liquid
亚型 :IgG
免疫原 :Synthetic peptide within human MCL1 aa 58-130.
规格 :50μl/100μl
B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.杭州华安生物技术有限公司
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入驻年限:7年