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供应商 :上海晶抗生物工程有限公司
库存 :大量
克隆性 :多克隆
保质期 :1年
抗体英文名 :Anti-SPAM1 antibody
宿主 :Rabbit
适应物种 :Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,Sheep
应用范围 :科研试验
保存条件 :-20°C
规格 :25 μl/100 μl/200 μl
Anti-SPAM1 antibodyCat. No. JK162907
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-SPAM1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human SPAM1
Reactivity Human
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol SPAM1
Full name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n
Swissprot P38567
Target Background
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
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入驻年限:9年