Anti-GFI1 antibody

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：大量

克隆性 ：多克隆

保质期 ：1年

抗体英文名 ：Anti-GFI1 antibody

宿主 ：Rabbit

浓度 ：1.86 mg/ml

保存条件 ：-20°C

规格 ：25 μl/100 μl/200 μl

Anti-GFI1 antibody

Cat. No.     JC263984
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-GFI1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human GFI1
Reactivity                 Human, Mouse, Rat
Content                     1.86 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 GFI1
Full name                 growth factor independent 1 transcriptional repressor
Synonyms    SCN2; GFI-1; GFI1A; ZNF163
Swissprot    Q99684

Target Background
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 50-300    Predicted cell location: Nucleus and Cytoplasm
Positive control: Human colorectal cancer
Recommended dilution: 50-300
            
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ml263984(GFI1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ml263984(GFI1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 5000-10000