FITC标记的同源结构域转录因子HESX1抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-13597R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-HESX1/FITC

抗体名 ：Anti-HESX1/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

适应物种 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：ICC=1:50-200 IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的同源结构域转录因子HESX1抗体

英文名称	Anti-HESX1/FITC
中文名称	FITC标记的同源结构域转录因子HESX1抗体
别    名	HESX1_HUMAN; Homeobox expressed in ES cells 1; Homeobox protein ANF; hAnf.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	免疫学  神经生物学  干细胞  转录调节因子  细胞粘附分子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用	ICC=1:50-200 IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	21kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human HESX1
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: The homeobox protein, HESX1, which is also known as Rathke’s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays. Function: Homeobox protein expressed in embryonic stem cells and targetd by Sox2, Oct4 and Nanog. Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor.  Subunit: Can form heterodimers with PROP1 in binding to DNA. Interacts with TLE1. Subcellular Location: Nuclear DISEASE: Septooptic dysplasia (SOD) [MIM:182230]: A clinically heterogeneous disorder defined by any combination of optic nerve hypoplasia, pituitary gland hypoplasia with panhypopopituitarism, and midline abnormalities of the brain, including absence of the corpus callosum and septum pellucidum. Note=The disease is caused by mutations affecting the gene represented in this entry. Growth hormone deficiency with pituitary anomalies (GHDPA) [MIM:182230]: A disease characterized by low or absent growth hormone levels, in the presence of a hypoplastic anterior pituitary lobe and ectopic or absent posterior pituitary lobe. Note=The disease is caused by mutations affecting the gene represented in this entry. Pituitary hormone deficiency, combined, 5 (CPHD5) [MIM:182230]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD5 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the ANF homeobox family. Contains 1 homeobox DNA-binding domain.  Database links: Entrez Gene: 8820 Human Omim: 601802 Human SwissProt: Q52LC5 Human SwissProt: Q9UBX0 Human Unigene: 171980 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.