FITC标记的唾液酸结合性免疫球蛋白样凝集素1抗体

FITC标记的唾液酸结合性免疫球蛋白样凝集素1抗体

价格: ¥2980

品牌:LMAI Bio

货号:LM-10236R-FITC

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供应商 :上海联迈生物工程有限公司

库存 :大量

靶点 :详见说明书

级别 :1

目录编号 :LM-10236R-FITC

克隆性 :多克隆

抗原来源 :Rabbit

保质期 :1年

抗体英文名 :Anti-Sialoadhesin/FITC

抗体名 :Anti-Sialoadhesin/FITC

标记物 :FITC标记

宿主 :Human, Mouse,

适应物种 :Human, Mouse,

免疫原 :详见说明书

亚型 :IGg

形态 :粉末、液体、冻干粉

应用范围 :ICC=1:50-200 IF=1:50-200

浓度 :1mg/ml

保存条件 :-20 °C

规格 :100ul

FITC标记的唾液酸结合性免疫球蛋白样凝集素1抗体
英文名称 Anti-Sialoadhesin/FITC
中文名称 FITC标记的唾液酸结合性免疫球蛋白样凝集素1抗体
别    名 CD169; CD 169; CD-169; CD169 antigen; dJ1009E24.1; DKFZp667F058; FLJ00051; FLJ00055; FLJ00073; FLJ00411; FLJ32150; Sialic acid binding Ig like lectin 1; Sialic acid binding immunoglobulin like lectin 1; Siglec 1; Siglec1; SN; sialoadhesin; SN_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  微生物学  b-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 186kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sialoadhesin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008].

Function:
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 
Contains 16 Ig-like C2-type (immunoglobulin-like) domains. 
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 6614 Human

Omim: 600751 Human

SwissProt: Q9BZZ2 Human

Unigene: 31869 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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