Anti-MAP2K2 antibody

供应商 ：上海晶抗生物工程有限公司

库存 ：大量

克隆性 ：多克隆

保质期 ：1年

抗体英文名 ：Anti-MAP2K2 antibody

宿主 ：Rabbit

适应物种 ：Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,Sheep

应用范围 ：科研试验

保存条件 ：-20°C

规格 ：25 μl/100 μl/200 μl

Anti-MAP2K2 antibody


Cat. No.     JK160582
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MAP2K2 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human MAP2K2
Reactivity                 Human, Mouse, Rat
Content                     1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 MAP2K2
Full name                 mitogen-activated protein kinase kinase 2
Synonyms    MEK2, MKK2, MAPKK2, PRKMK2
Swissprot    P36507

Target Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.