AZD5363（Capivasertib）

英文名 ：≥98%(HPLC)

库存 ：50

CAS号 ：1143532-39-1

规格 ：5mg/25mg/100mg

一种有效的pan-AKT激酶抑制剂，抑制Akt1、Akt2和Akt3，IC50分另为3nM、8nM和8nM。AZD5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components。