FIIN-2

英文名 ：≥98%（HPLC）

库存 ：50

CAS号 ：1633044-56-0

规格 ：5mg/25mg

一种有效的、选择性的、不可逆的FGFR抑制剂，对FGFR1/2/3/4的IC50分别为3.09nM、4.3nM、27nM和45.3nM。FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip。