Cobimetinib

英文名 ：≥98%（HPLC）

库存 ：50

CAS号 ：934660-93-2

规格 ：5mg/25mg/100mg

一种口服的MEK抑制剂，具有潜在的抗肿瘤活性，抑制MEK1的IC50为4.2nM。Cobimetinib is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor GDC-0973 specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types。