Vandetanib(AZD6474)

英文名 ：≥98%（HPLC）

库存 ：50

CAS号 ：443913-73-3

规格 ：100mg/1g

一种VEGF2抑制剂，IC50：40nM。Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis。