SSRP1 Antibody

保存条件 ：低温

保质期 ：一年

英文名 ：SSRP1 Antibody

库存 ：大量

供应商 ：科敏商城

CAS号 ：WB ,

规格 ：100 ul (10 western blots)

品牌:CST，产品名称：SSRP1 Antibody #12009
英文名称：SSRP1 Antibody
Product name：SSRP1 Antibody #12009
Isotype：Rabbit IgG
Sensitivity：Endogenous
MW(kDa)：81
Applications：WB ,
Purification： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu148 of human SSRP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background： Suppressor of Ty-16 (SPT16) and structure-specific recognition protein-1 (SSRP1) are subunits of the facilitates chromatin transcription (FACT) complex that is essential for transcription elongation (1,2). FACT facilitates RNA polymerase-dependent transcription of chromatin templates by destabilizing the nucleosomes within the open reading frames of active genes (3-5). FACT destabilizes the nucleosomes, which would otherwise act as barriers to RNA polymerase transcription activity, by disrupting histone-histone and histone-DNA contacts that lead to the eviction of the histone H2A-H2B dimer (2,3,6). FACT may also function as a histone chaperone to reassemble nucleosomes after RNA polymerase passage (7). In addition to transcription, FACT activity has been shown to have a role in DNA replication in yeast and in DNA repair by contributing to the activation of p53 by CK2 and by facilitating histone H2AX-H2B exchange upon DNA damage (8-10).

Entrez-Gene Id

6749

Swiss-Prot Acc.

Q08945

Specificity / Sensitivity:

SSRP1 Antibody recognizes endogenous levels of total SSRP1 protein. This antibody also cross-reacts with a protein of unknown origin at 150 kDa.

Species Reactivity:

Human, Mouse, Rat, Monkey

Species predicted to react based on 100% sequence homology:

Hamster, Bovine, Guinea Pig, Horse

Application	Dilutions
Western Blotting	1:1000

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.