PD-L1 (E1L3N)  (HRP)

保存条件 ：低温

保质期 ：一年

英文名 ：PD-L1 (E1L3N®) XP® Rabbit mAb (HRP Conjugate)

库存 ：大量

供应商 ：科敏商城

CAS号 ：WB ,

规格 ：100 ul (10 western blots)

品牌:CST，产品名称：PD-L1 (E1L3N) XP Rabbit mAb (HRP Conjugate) #51296
英文名称：PD-L1 (E1L3N®) XP® Rabbit mAb (HRP Conjugate)
Product name：PD-L1 (E1L3N^®) XP^® Rabbit mAb (HRP Conjugate) #51296
Applications：WB ,
Purification： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PD-L1 protein.
Background： Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).

Entrez-Gene Id

29126

Swiss-Prot Acc.

Q9NZQ7

Specificity / Sensitivity:

PD-L1 (E1L3N^®) XP^® Rabbit mAb (HRP Conjugate) recognizes endogenous levels of total PD-L1 protein.

Species Reactivity:

Human

Application	Dilutions
Western Blotting	1:1000

Storage:

Supplied in 136 mM NaCl, 2.6 mM KCl, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibodies.

Product Description:

This Cell Signaling Technology antibody is conjugated to the carbohydrate groups of horseradish peroxidase (HRP) via its amine groups. The HRP conjugated antibody is expected to exhibit the same species cross-reactivity as the unconjugated PD-L1 (E1L3N^®) XP^® Rabbit mAb #13684.