Neuropilin-2 (D39A5)

保存条件 ：低温

保质期 ：一年

英文名 ：Neuropilin-2 (D39A5) XP® Rabbit mAb

库存 ：大量

供应商 ：科敏商城

CAS号 ：WB , IP , IHC , IF ,

规格 ：20 ul (2 western blots)

品牌:CST，产品名称：Neuropilin-2 (D39A5) XP Rabbit mAb #3366
英文名称：Neuropilin-2 (D39A5) XP® Rabbit mAb
Product name：Neuropilin-2 (D39A5) XP^® Rabbit mAb #3366
Isotype：Rabbit IgG
Sensitivity：Endogenous
MW(kDa)：120
Applications：WB , IP , IHC , IF ,
Purification： Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse Neuropilin-2 protein.
Background： Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single pass, transmembrane signaling proteins encompassing Plexin A1, A2, A3 and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).Neuropilin-2, a single pass, transmembrane glycoprotein, can also bind to VEGF165 and VEGF145, but not VEGF121. Thus, in addition to neuronal guidance, neuropilin-2 plays a role in angiogenesis and cardiovascular functions (4). Although neuropilin-2 has been linked to tumor biology (e.g. pancreatic cancer, bladder cancer, lung cancer, and neuroblastoma), its role in tumor pathogenesis is still under investigation (4,5).

Entrez-Gene Id

8828

Swiss-Prot Acc.

O60462

Specificity / Sensitivity:

Neuropilin-2 (D39A5) XP^® Rabbit mAb detects endogenous levels of total neuropilin-2 protein.

Species Reactivity:

Mouse, Rat

Application	Dilutions
Western Blotting	1:1000
Immunoprecipitation	1:50
Immunohistochemistry (Paraffin)	1:100
Immunofluorescence (Frozen)	1:2000

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.