Cleaved Drosophila ICE (drICE) (Asp230) Antibody

保存条件 ：低温

保质期 ：一年

英文名 ：Cleaved Drosophila ICE (drICE) (Asp230) Antibody

库存 ：大量

供应商 ：科敏商城

CAS号 ：WB ,

规格 ：100 ul (10 western blots)

品牌:CST，产品名称：Cleaved Drosophila ICE (drICE) (Asp230) Antibody #9478
英文名称：Cleaved Drosophila ICE (drICE) (Asp230) Antibody
Product name：Cleaved Drosophila ICE (drICE) (Asp230) Antibody #9478
Isotype：Rabbit IgG
Sensitivity：Endogenous
MW(kDa)：45, 55
Applications：WB ,
Purification： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino-terminal residues adjacent to Asp230 of Drosophila ICE protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background： Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases and four encode effector caspases (reviewed in 2). drICE is a cysteine protease that cleaves baculovirus p35 and lamin DmO in vitro and acts downstream of rpr (3). drICE is proteolytically processed during apoptosis into active p21 and p12 subunits. Comparison of the in vivo activity between drICE and Dcp-1 has shown that drICE is a more effective inducer of apoptosis than Dcp-1, which plays a role in determining the rate of cell death (4).

Entrez-Gene Id

43514

Swiss-Prot Acc.

O01382

Specificity / Sensitivity:

Cleaved Drosophila ICE (drICE) (Asp230) Antibody recognizes endogenous levels of the large 21 kDa fragment of cleaved drICE. This antibody also detects low levels of full length drICE (35 kDa).

Species Reactivity:

D. melanogaster

Application	Dilutions
Western Blotting	1:1000

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.