CD38 Antibody

保存条件 ：低温

保质期 ：一年

英文名 ：CD38 Antibody

库存 ：大量

供应商 ：科敏商城

CAS号 ：WB ,

规格 ：100 ul (10 western blots)

品牌:CST，产品名称：CD38 Antibody #14637
英文名称：CD38 Antibody
Product name：CD38 Antibody #14637
Source：Rabbit
Sensitivity：Endogenous
MW(kDa)：45
Reactivity：H
Applications：WB ,
Purification： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn229 of human CD38 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background： Cyclic ADP-ribose hydrolase 1 (CD38) is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP ribose (cADPR) from NAD (1,2). Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) from NADP⁺. Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca²⁺ stores (3-6). Since CD38 is the primary mammalian NAD⁺ glycohydrolase responsible for NAD⁺ metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD⁺-dependent pathways (7,8). CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia (9-11).

Entrez-Gene Id

952

Swiss-Prot Acc.

P28907

Specificity / Sensitivity:

CD38 Antibody recognizes endogenous levels of total CD38 protein.

Species Reactivity:

Human

Application	Dilutions
Western Blotting	1:1000

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.