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供应商 :上海机纯实业有限公司
库存 :大量
克隆性 :多克隆
保质期 :12个月
抗体英文名 :Anti-NLRP3 antibody
宿主 :Rabbit
适应物种 :人/动物/植物
应用范围 : ELISA, WB
浓度 :0.1 mg/ml
保存条件 : -20°C
规格 :25 μl/100 μl/200 μl
Anti-NLRP3 antibodyCat. No. JC120143
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-NLRP3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human NLRP3
Reactivity Human
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-NLRP3 antibody
Target information
Symbol NLRP3
Full name NLR family, pyrin domain containing 3
Synonyms AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
Swissprot Q96P20
Target Background
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
Anti-NLRP3 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human esophagus cancer
Recommended dilution: 15-50 Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 15-50
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入驻年限:8年