FITC标记的转录调节蛋白BACH2抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-12563R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-BACH2/FITC

抗体名 ：Anti-BACH2/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,

适应物种 ：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：ICC=1:50-200 IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的转录调节蛋白BACH2抗体

英文名称	Anti-BACH2/FITC
中文名称	FITC标记的转录调节蛋白BACH2抗体
别    名	Bach 2; Bach2; BACH2_HUMAN; Basic leucine zipper transcription factor 2; BTB and CNC homolog 2; BTB and CNC homology 1 basic leucine zipper transcription factor 2; OTTHUMP00000016867; OTTHUMP00000016868; OTTHUMP00000040591; Transcription regulator protein BACH2.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	肿瘤  细胞生物  信号转导  转录调节因子  淋巴细胞  b-淋巴细胞  新陈代谢
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
产品应用	ICC=1:50-200 IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	92kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human BACH2
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. They dimerize with other proteins and bind DNA to either represse or activate transcription depending on the dimer compositions. BACH1 and BACH2, heterodimerization partners of MafK, are members of a novel family of BTB/POZ-basic region leucine zipper (bzip) factors. BACH1 and BACH2 have significant similarity to each other in BTB domain and Cap ‘n’ collar-type bZip domain but are otherwise divergent. BACH1 appears ubiquitous, whereas BACH2 is restricted to monocytes, neuronal cells and is abundantly expressed in the early stages of B-cell differentiation. BACH2, a 841 amino acid polypeptide, is an Nrf2-related transcription repressor and a tissue-specific partner of the Maf oncoprotein family. In culture cells, BACH2 is localized to the cytoplasm through its C-terminal cytoplasmic localization signal (CLS). Oxidative stressors aborted the CLS activity and induce nuclear accumulation of BACH2, which mediates nucleocytoplasmic communciation to couple oxidative stress and transcription repression in mammalian cells. BACH2 heterodimerizes with MAZR through its BTB/POZ domain to activate transcription. BACH2 also plays an important role in the regulation of B cell development. Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK. Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity). Subcellular Location: Nucleus. Tissue Specificity: B-cell specific. Similarity: Belongs to the bZIP family. CNC subfamily. Contains 1 BTB (POZ) domain. Contains 1 bZIP domain. Database links: Entrez Gene: 60468 Human Entrez Gene: 12014 Mouse Entrez Gene: 366340 Rat Omim: 605394 Human SwissProt: Q9BYV9 Human SwissProt: P97303 Mouse Unigene: 269764 Human Unigene: 431426 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.