FITC标记的磷酸化丝裂原活化蛋白激酶磷酸酶p38γ抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-12001R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-phospho-SAPK3 (Thr183+Tyr185)/FITC

抗体名 ：Anti-phospho-SAPK3 (Thr183+Tyr185)/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig,

适应物种 ：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：ICC=1:50-200 IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的磷酸化丝裂原活化蛋白激酶磷酸酶p38γ抗体

英文名称	Anti-phospho-SAPK3 (Thr183+Tyr185)/FITC
中文名称	FITC标记的磷酸化丝裂原活化蛋白激酶磷酸酶p38γ抗体
别    名	p-SAPK3(phospho-Thr183+Tyr185); MAP kinase 12; MAP kinase p38 gamma; MAPK 12; Mapk12; Mitogen Activated Protein Kinase 12; ERK6; ERK 6; ERK-6; Extracellular signal-regulated kinase 6; Mitogen activated protein kinase 3; Mitogen activated protein kinase p38 gamma; Mitogen-activated protein kinase 12; Mitogen-activated protein kinase p38 gamma; MK12_HUMAN; P38 GAMMA; P38GAMMA; PRKM12; SAPK 3; SAPK3; Stress Activated Protein Kinase 3; Stress-activated protein kinase 3.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
产品类型	磷酸化抗体
研究领域	细胞生物  信号转导  细胞凋亡  激酶和磷酸酶  细胞粘附分子  细胞分化
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig,
产品应用	ICC=1:50-200 IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	42kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthesised phosphopeptide derived from human SAPK3 around the phosphorylation site of Thr183+Tyr185 [EM(p-T)G(p-Y)VV]
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38 alpha, p38 beta and p38 gamma, also known as MAPK14, MAPK11 and MAPK12, respectively, each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38 alpha, p38 beta and p38 gamma are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation. The p38 proteins are subject to phosphoryation on Thr and Tyr residues, an event which is thought to activate the phosphorylated protein.  Function: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.  Subcellular Location: Cytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.  Tissue Specificity: Highly expressed in skeletal muscle and heart. Post-translational modifications: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.  Database links: Entrez Gene: 6300 Human Entrez Gene: 29857 Mouse Omim: 602399 Human SwissProt: P53778 Human SwissProt: O08911 Mouse Unigene: 432642 Human Unigene: 38343 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.