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供应商 :上海联迈生物工程有限公司
库存 :大量
靶点 :详见说明书
级别 :1
目录编号 :LM-11913R-FITC
克隆性 :多克隆
抗原来源 :Rabbit
保质期 :1年
抗体英文名 :Anti-NPDC1/FITC
抗体名 :Anti-NPDC1/FITC
标记物 :FITC标记
宿主 :Human, Mouse, Rat,
适应物种 :Human, Mouse, Rat,
免疫原 :详见说明书
亚型 :IGg
形态 :粉末、液体、冻干粉
应用范围 :ICC=1:50-200 IF=1:50-200
浓度 :1mg/ml
保存条件 :-20 °C
规格 :100ul
FITC标记的神经细胞增殖和分化调控蛋白1抗体英文名称 | Anti-NPDC1/FITC |
中文名称 | FITC标记的神经细胞增殖和分化调控蛋白1抗体 |
别 名 | AI314472; CAB1; Neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; NPDC1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 神经生物学 细胞凋亡 细胞周期蛋白 细胞分化 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 31kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human NPDC1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human. Function: Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Tissue Specificity: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe. Similarity: Belongs to the NPDC1/cab-1 family. Database links: Entrez Gene: 56654 Human Entrez Gene: 18146 Mouse Entrez Gene: 296562 Rat Omim: 605798 Human SwissProt: Q9NQX5 Human SwissProt: Q64322 Mouse Unigene: 719906 Human Unigene: 1131 Mouse Unigene: 5802 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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入驻年限:8年