Anti-F13A1 antibody

供应商 ： 上海晶抗生物工程有限公司

库存 ：大量

克隆性 ：多克隆

保质期 ：1年

抗体英文名 ：Anti-F13A1 antibody

宿主 ：Rabbit

适应物种 ： Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,Sheep

应用范围 ：科研试验

保存条件 ：-20°C

规格 ：25 μl/100 μl/200 μl

Anti-F13A1 antibody

Cat. No.    JK261169    
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol


Product overview
Description                   Anti-F13A1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human F13A1
Reactivity                 Human, Mouse, Rat
Content                     0.7 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 F13A1
Full name                 coagulation factor XIII, A1 polypeptide
Synonyms    F13A
Swissprot    P00488

Target Background
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.