FITC标记的P选择素/白细胞内皮细胞粘附分子3抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-0561R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-CD62p/FITC

抗体名 ：Anti-CD62p/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse,

适应物种 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：Flow-Cyt=1:50-200 IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的P选择素/白细胞内皮细胞粘附分子3抗体

英文名称	Anti-CD62p/FITC
中文名称	FITC标记的P选择素/白细胞内皮细胞粘附分子3抗体
别    名	CD62 antigen-like family member P; GMP 140; GMP-140; GMRP; Granule membrane protein 140; Granulocyte membrane protein; GRMP; LECAM 3; LECAM3; Leukocyte endothelial cell adhesion molecule 3; Leukocyte-endothelial cell adhesion molecule 3; LYAM3_HUMAN; P Selectin; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; PSEL.
	Journal PMID IF Application BioMed Research International (2012) 22505807 2.8800 FCM International Journal of Rheumatology (2012) 22611405 1.6500 FCM
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	心血管  细胞生物  免疫学  干细胞  细胞粘附分子  上皮细胞
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用	Flow-Cyt=1:50-200 IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	88kDa
细胞定位	细胞膜
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human P-selectin
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Subunit: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. DISEASE: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Similarity: Belongs to the selectin/LECAM family.  Contains 1 C-type lectin domain.  Contains 1 EGF-like domain.  Contains 9 Sushi (CCP/SCR) domains. Database links: Entrez Gene: 6403 Human Entrez Gene: 20344 Mouse Entrez Gene: 25651 Rat Omim: 173610 Human SwissProt: P16109 Human SwissProt: Q01102 Mouse SwissProt: P98106 Rat Unigene: 73800 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  P-选择素(P—selectin)是细胞黏附分子选择素家族的主要成员，又称CD62p，可以介导各种白细胞和肿瘤细胞的粘附。 CD62p又称GMP—140或PADGEM蛋白(血小板活化依赖α颗粒膜蛋白),它在血小板与单核细胞及中性粒细胞相互作用中起关键作用