FITC标记的X射线修复交叉互补蛋白抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-1218R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-XRCC1/FITC

抗体名 ：Anti-XRCC1/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat,

适应物种 ：Human, Mouse, Rat,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的X射线修复交叉互补蛋白抗体

英文名称	Anti-XRCC1/FITC
中文名称	FITC标记的X射线修复交叉互补蛋白抗体
别    名	DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray repair complementing defective repair in chinese hamster cells 1; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair cross complementing protein 1; RCC; X ray repair, complementing defective, repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN; XRCC 1.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	肿瘤  染色质和核信号  新陈代谢  表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat,
产品应用	IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	69kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human XRCC1
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. In testis XRCC1 is expressed at high levels. Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Subunit: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.  Subcellular Location: Nucleus. Note=Accumulates at sites of DNA damage. Post-translational modifications: Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. Sumoylated. Similarity: Contains 2 BRCT domains. Database links: Entrez Gene: 7515 Human Entrez Gene: 22594 Mouse Entrez Gene: 84495 Rat Omim: 194360 Human SwissProt: P18887 Human SwissProt: Q60596 Mouse SwissProt: Q9ESZ0 Rat Unigene: 98493 Human Unigene: 4347 Mouse Unigene: 13754 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  XRCC-1是一种重要的DNA修复基因,在一系列内外氧化剂(包括烟草成分)导致的DNA单链断裂和碱基损伤修复中起到重要作用,是目前肿瘤研究的重要的蛋白。