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Morroniside

CAS No. : 25406-64-8

MCE 国际站：Morroniside

产品活性：Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用。

研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  Apoptosis

作用靶点：MMP  |  Pyroptosis  |  Apoptosis

In Vivo: Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R‑associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase‑3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl‑2 is significantly downregulated. The expression of active caspase‑3 and Bax is significantly downregulated by Morroniside treatment in a dose‑dependent manner, while the expression of Bcl‑2 is significantly upregulated. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.

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