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保存条件 :4°C, stored under nitrogen
库存 :货期:1-2天
供应商 :MedChemExpress LLC
CAS号 :625-08-1
规格 :10 mM * 1 mL/500 mg/1 g
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3-Hydroxyisovaleric acid
CAS No. : 625-08-1
MCE 国际站:3-Hydroxyisovaleric acid
产品活性:3-Hydroxyisovaleric acid 是尿液中排泄的正常内源性代谢产物 (endogenous metabolite)。3-Hydroxyisovaleric acid 的尿排泄是生物素缺乏的早期和敏感指标。
研究领域:Metabolic Enzyme/Protease
结构分类:酮、醛、酸
In Vitro: The reduced activity of methylcrotonyl-CoA carboxylase (MCC) leads to an elevated excretion of 3-methylcrotonic acid, the product of its hydration (3-hydroxyisovaleric acid: 3-HIA), and 3-methylcrotonylglycine, formed by conjugation with glycine.
In Vivo: In male mice (ICR/Jcl) at 8 weeks of age fed the biotin-deficient diet for 6 weeks, the concentration of urinary 3-Hydroxyisovaleric acid is 114.2 mM creatinine, which is higher than the concentration of 35.2 mM creatinine in mice fed the biotin-deficient diet for 4 weeks.
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