三(2-羧乙基)膦 盐酸盐

库存 ：大量

英文名 ：Tris(2-carboxyethyl)phosphine hydrochloride

CAS号 ：51805-45-9

保质期 ： 2年

供应商 ：上海瓦兰生物

保存条件 ： 2-8℃

规格 ：2G

性质

Related Categories	Antioxidants and Reducing Agents for Protein Stabilization, Chemical Synthesis, Other Synthetic Reagents for Reduction, Reagents for Protein Stabilization, Reduction, 更多...
description	Protect from moisture
InChI Key	PBVAJRFEEOIAGW-UHFFFAOYSA-N
form	powder
color	white
solubility	H2O: 50 mg/mL
storage temp.	2-8°C

产品描述

Application

水溶性试剂，用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) may be employed as catalyst for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides.1 It may be used as reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane.^[4]

When basified, this water-soluble ligand allows for simple removal of ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture.^[2][3]

用于在水中进行的二硫化物选择性还原。^[1]

Caution

Storage conditions:protect from moisture.

包装

2, 10, 50 g in glass bottle

General description

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1^[4] It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1^[4] It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins.1 TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).^[5]