Rabbit anti-ALG2 8522

保存条件 ：After reconstitution freeze in small aliquots (e.g. 1 µl). For long storage, keep at - 80°C (or at least - 20°C). For continuous use keep at 4°C (with 0.01% Naazide). Avoid repeated freezing and thawing.

克隆性 ：多克隆

适应物种 ：Rabbit

供应商 ：上海联迈生物工程有限公司

应用范围 ：Immunohistochemistry: 1:2'000 - 1:5'000 with the avidin-biotin method. On paraformaldehyde (4%) or formalin-fixed tissue. Cryostate sections. Immunoblots: 1:1’000 - 1:2'000. We recommend that the optimal dilutions be determined by titration experiments.

靶点 ：ALG-2 (8522) Apoptosis linked gene

规格 ：200 µl.

商品分类：Antibodies against Ca2+ -bindin

研究领域：Others

存储溶液：Lyophilized antiserum (no preservatives).

参考文献：1. Vito, P., Lacana, E. & D'Adamio, L. Science 271, 521-525 (1996).2. Tarabykina, S., Læssø Møller, A., Durussel, I., Cox, J. and Berchtold, M.W., J. Biol. Chem. 275, 10514-10518(2000).3. La Cour JM, Moellerup J., Winding P., Tarabykina S., Sehested M. and Berchtold MW, Am. J. Pathol., 163, 81-89 (2003).

应用：Immunohistochemistry: 1:2'000 - 1:5'000 with the avidin-biotin method. On paraformaldehyde (4%) or formalin-fixed tissue. Cryostate sections.Immunoblots: 1:1’000 - 1:2'000.We recommend that the optimal dilutions be determined by titration experiments.

官网链接：https://www.swant.com/pdfs/Rabbit_anti_ALG2_mb-2.pdf

商品关键词：Rabbit anti-ALG2 8522,Mb-2-200 µl.,Swant

简单描述：In many apoptotic pathways Ca2+ seems to play an important role. The Ca2+ binding protein ALG-2 is an apoptotic protein discovered in a death trap assay and described as a proapoptotic protein by the group of D'Adamio (1). The protein of 191 amino acids contains two canonical Ca2+ binding EF-hand domains, binding Ca2+ with high affinity and one non canonical EF-hand, binding Ca2+ with low affinity. Cells lacking ALG-2 still contain active caspases but are protected against apoptosis induced by Fas, glucocorticoids and staurosporin. The protein is expressed ubiquitously and was conserved during evolution from C.elegans to man (2). Expression of ALG-2 is increased in various cancers (3). This antiserum was made against the full-length recombinant ALG2-protein.

Lot No: 18299

Reconstitution: with 200 µl bidistilled water.

Product: Antiserum

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