FITC标记的Smad核转录共抑制因子抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

靶点 ：详见说明书

级别 ：1

目录编号 ：LM-5945R-FITC

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：Anti-SnoN/FITC

抗体名 ：Anti-SnoN/FITC

标记物 ：FITC标记

宿主 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

适应物种 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

免疫原 ：详见说明书

亚型 ：IGg

形态 ：粉末、液体、冻干粉

应用范围 ：IF=1:50-200

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

FITC标记的Smad核转录共抑制因子抗体

英文名称	Anti-SnoN/FITC
中文名称	FITC标记的Smad核转录共抑制因子抗体
别    名	SKI like; Ski related oncogene; Ski related protein; SKIL; SnoA; SNO; SnoA; SnoI; SnoN; SKIL_HUMAN.
规格价格	100ul/2980元 购买        大包装/询价
说 明 书	100ul
研究领域	肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用	IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	77kDa
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human SnoN
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. Function: May have regulatory role in cell division or differentiation in response to extracellular signals. Subunit: Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Tissue Specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Similarity: Belongs to the SKI family. Database links: UniProtKB/Swiss-Prot: P12757.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  Smad核转录共抑制因子(SnoN)是一种拮抗剂，可严格调控转化生长因子-β1/smad(TGF-β1/Smad)信号的活性，从而保证在正常的生理条件下TGF-β1/smad信号输出的稳定性