大鼠CD28功能性抗体（T细胞激活扩增）

价格： ¥4000

品牌：peprotech

货号：10313-25

产品详情

Description

The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2).

Additional Information

Clone:	JJ319
Format:	SAFIRE Purified
Applications:	FC, FA
Reactivity:	Rat
Isotype:	Mouse IgG1
Research Interest:	Adaptive Immunity
Cell Type:	T Cells
Preparation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:	Phosphate-buffered aqueous solution, ph7.2.
References:	Tacke, M., Clark, G. J., Dallman, M. J., & Hünig, T. (1995). Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. The Journal of Immunology, 154(10), 5121-5127. Tacke, M., Hanke, G., Hanke, T., & Hünig, T. (1997). CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28. European journal of immunology, 27(1), 239-247. Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2(6), 555-559.