mTOR相关调控蛋白抗体价格

mTOR相关调控蛋白抗体价格

价格: 询价

品牌:上海博湖

货号:BH-K21581

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抗体名 :mTOR相关调控蛋白抗体价格

抗体英文名 :Anti-Raptor

靶点 :详见说明书

浓度 :1mg/1ml

应用范围 :WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

宿主 :详见说明书

供应商 :上海博湖

库存 :大量

级别 :详见说明书

目录编号 :详见说明书

抗原来源 :Rabbit

保质期 :详见说明书

适应物种 :详见说明书

标记物 :详见说明书

克隆性 :多克隆

保存条件 :Store at -20 °C

形态 :大量

亚型 :IgG

免疫原 :KLH conjugated synthetic peptide derived from human Raptor

规格 :0.2ml/200μg

英文名称  Anti-Raptor
中文名称  mTOR相关调控蛋白抗体价格
     p150 target of rapamycin (TOR) scaffold protein containing WD repeats; P150 target of rapamycin (TOR)-scaffold protein; Regulatory Associated Protein of mTOR; KIAA1303; RPTOR_HUMAN; Regulatory-associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold protein.


     1mg/1ml
 0.2ml/200μg
抗体来源  Rabbit
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit
产品类型  一抗  
研究领域  肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子
蛋白分子量  predicted molecular weight: 147kDa 
     Lyophilized or Liquid
 KLH conjugated synthetic peptide derived from human Raptor
     IgG
纯化方法   affinity purified by Protein A
 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide


mTOR相关调控蛋白抗体价格产品应用  WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
产品介绍 mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

Function : Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
Subunit : Interacts with MTOR (By similarity). Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR and AKT1S1. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Binds directly to 4EBP1 and RPS6KB1 independently of its association with MTOR. Binds preferentially to poorly or non-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation. Forms a complex with MTOR under both leucine-rich and -poor conditions. Interacts with ULK1 in a nutrient-dependent manner; the interaction is reduced during starvation. Interacts (when phosphorylated by AMPK) with 14-3-3 protein, leading to inhibit its activity.
Subcellular Location : Cytoplasm. Lysosome. Note=Targeting to lysosomes depends on amino acid availability.
Tissue Specificity : Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
Post-translational modifications : In response to nutrient limitation, phosphorylated by AMPK; phosphorylation promotes interaction with 14-3-3 proteins, leading to negative regulation of the mTORC1 complex. In response to growth factors, phosphorylated at Ser-719, Ser-721 and Ser-722 by RPS6KA1; phosphorylation positively stimulates mTORC1 activity.
Similarity : Belongs to the WD repeat RAPTOR family.
Contains 7 WD repeats.
Database links : UniProtKB/Swiss-Prot: Q8N122.1
乳类雷帕霉素靶蛋白(mTOR)信号通路是涉及细胞增长、肿瘤、炎症、和纤维化的重要信号通路,其相关分子Raptor也是目前的研究热点。


mTOR相关调控蛋白抗体价格具有全、新、优、品、好四大特点:
全:公司提供上万种产品,涵盖了生物试剂,elisa试剂盒,标准品,培养基,原装耗材,抗体、培养基、ATCC细胞等,基本上各种科研所需产品在我司都能找到。
新:产品更新速度较快,基本上每周都有新产品出现。
优:产品质量好,投诉比较少。
好:我公司具有优质的技术团队,产品一旦售出,实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务,可根据您科研的需求,满足您的需要,质量保证,价格合理。
一、标记流程
委托标记服务,请下载并详细填写《委托标记申请单》,待我公司标记室技术人员研究、确认后答复,并办理委托标记事宜。
二、各种标记物制备的收费标准(RMB 
我们不但提供抗体和大分子蛋白的标记服务,还提供小分子多肽及小分子蛋白的各种标记服务,提供标记化合物的服务(此化合物必须适用于标记),价格另议。
一抗和二坑的区别:
第一抗体就是平常所说的抗体,即能和抗原特异性结合。
第二抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体,二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说,抗原进入机体刺激机体免疫系统产生免疫应答,由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团,而且一抗可以至少结合两种其他基团(底物和二抗)。
一抗:可以特异结合底物,就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗:可以和一抗结合,并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),则不需要二抗。但这样成本很高,因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记,再来检测一抗。而一抗识别底物。这样,当一抗结合到底物上,就可以通过二抗检测出来。 


Anti-SYVN1/FITC 荧光素标记滑膜细胞凋亡抑制物1抗体IgGMulti-class antibodies规格: 0.2ml
IGFBP-5 ( Insulin-like Growth Factor Binding Protein 5IBP5) 胰岛素样生长因子结合蛋白-5(抗原)Multi-class antibodies规格: 0.5mg
Ras相关区域家族1A抗体 Anti-RASSF1A 0.2ml
SVH 英文名称: 肝癌蛋白剪接变异体蛋白抗体 0.2ml
EFHC2 英文名称: EFHC2蛋白抗体 0.2ml
Rhesus antibody Rh phospho-MK5(Se9) 化原活化蛋白激酶激酶5抗体 规格 0.1ml
IGFBP-5 ( Insulin-like Growth Factor Binding Protein 5IBP5) 胰岛素样生长因子结合蛋白-5(抗原)Multi-class antibodies规格: 0.5mg
GABA/BSA γ1基偶联血清白蛋白Multi-class antibodies规格: 1mg

Anti-HER4/ErbB4 HER4抗体Multi-class antibodies规格: 0.2ml
Rhesus antibody Rh OAT-1/SLC22A6 阴离子转运蛋白-1抗体 规格 0.1ml
HRP/Horseradish Peroxidase 辣根过氧化物酶(辣根酶) 10mg
TRP2 英文名称: 酪酸酶相关蛋白2抗体 0.2ml
c-Maf 英文名称: 原癌基因cMAF抗体 0.2ml
Anti-HER4/ErbB4 HER4抗体Multi-class antibodies规格: 0.2ml
SLTM 英文名称: 雌激素诱导的转录调制器抗体 0.1ml

EGR2 英文名称: 早期生长反应蛋白2抗体 0.1ml
神经肽 Y抗体 Anti-NPY Neuropeptide Y) 0.1ml
Anti-SLC16A3/MCT-4/FITC 荧光素标记MCT4抗体IgGMulti-class antibodies规格: 0.2ml
Rhesus antibody Rh phospho-P53(Ser37) 化抑制基因P53抗体 规格 0.1ml
ACE2(Angiotensin converting enzyme 2) 血管紧张素转换酶2抗原Multi-class antibodies规格: 0.5mg
小鼠抗透明带抗体elisa试剂盒   小鼠抗透明带抗体试剂盒   规格型号:96T/48T   小鼠抗透明带抗体试剂盒,规格型号:96T/48T,来源:elisa试剂盒(进口分装),产品别名:小鼠抗透明带抗体试剂盒、小鼠抗透明带抗体eisa试剂盒   保存条件:2-8   保质期:6个月。

小鼠抗平滑肌抗体elisa试剂盒   小鼠抗平滑肌抗体试剂盒   规格型号:96T/48T   小鼠抗平滑肌抗体试剂盒,规格型号:96T/48T,来源:elisa试剂盒(进口分装),产品别名:小鼠抗平滑肌抗体试剂盒、小鼠抗平滑肌抗体eisa试剂盒   保存条件:2-8   保质期:6个月。
小鼠抗凝血酶受体elisa试剂盒   小鼠抗凝血酶受体试剂盒   规格型号:96T/48T   小鼠抗凝血酶受体试剂盒,规格型号:96T/48T,来源:elisa试剂盒(进口分装),产品别名:小鼠抗凝血酶受体试剂盒、小鼠抗凝血酶受体eisa试剂盒   保存条件:2-8   保质期:6个月。
小鼠抗凝血酶Ⅲ抗体elisa试剂盒   小鼠抗凝血酶Ⅲ抗体试剂盒   规格型号:96T/48T   小鼠抗凝血酶Ⅲ抗体试剂盒,规格型号:96T/48T,来源:elisa试剂盒(进口分装),产品别名:小鼠抗凝血酶Ⅲ抗体试剂盒、小鼠抗凝血酶Ⅲ抗体eisa试剂盒   保存条件:2-8   保质期:6个月。
大鼠激活素A(Activin A)ELISA试剂盒 ,英文名: Activin A ELISA Kit

Mouse Ureaplasma urealyticum aibody (UU-Ab) ELISA Kit 小鼠解脲脲原体抗体(UU-Ab)ELISA试剂盒
MouseCollagenaseIELISAKit 小鼠胶原酶I(CollagenaseI)ELISA试剂盒 96T/48T 进口分装
CLIAKitforHumanPancreaticcarcinomamarkers-CA242ELISAKit人胰腺癌标志物CA242规格:48T/96T
同位素标记放射活性滤膜法检测试剂盒20
ELISAKitP-PKC大鼠化蛋白激酶C规格:48T/96T
mTOR相关调控蛋白抗体价格小鼠甘油-3-脱酶(GAPDH/G3PDH)ELISA试剂盒 ,英文名: GAPDH/G3PDH ELISA Kit

大鼠氧化低密度脂蛋白抗体(OLAb)ELISA检测试剂盒Ratoxidizedlowdensitylipoproteinaibody,OLAbELISAKit 96T/48T
人白介素2可溶性受体α链(IL-2sRα/CD25)免疫试剂盒 Human IL-2sRα ELISA Kit
英文名称MouseTissuefactorpathwayinhibitorELISAKit小鼠组织因子途径抑制物(TFPI)规格:96T/48T
PARP蛋白免疫共沉淀分析试剂盒5
Porcineplateletactivatingfactor,PAFELISA试剂盒猪血小板活化因子(PAF)ELISA试剂盒规格:96T/48T
mTOR相关调控蛋白抗体价格是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品,产品品质卓越,价格实惠,多种规格供应,售后完善。
 

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