心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌

抗体名 ：心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌

抗体英文名 ：Anti-Ryanodine Receptor

靶点 ：详见说明书

浓度 ：1mg/1ml

应用范围 ：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

宿主 ：详见说明书

供应商 ：上海博湖

库存 ：大量

级别 ：详见说明书

目录编号 ：详见说明书

抗原来源 ：Rabbit

保质期 ：详见说明书

适应物种 ：详见说明书

标记物 ：详见说明书

克隆性 ：多克隆

保存条件 ：Store at -20 °C

形态 ：大量

亚型 ：IgG

免疫原 ：KLH conjugated synthetic peptide derived from human Ryanodine Receptor

规格 ：0.2ml/200μg

心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品，产品品质卓越，价格实惠，多种规格供应，售后完善。
英文名称  Anti-Ryanodine Receptor
中文名称  心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌
别    名  Arrhythmogenic right ventricular dysplasia 2; ARVC 2; ARVC2; ARVD 2; ARVD2; Brain ryanodine receptor calcium release channel; Brain type ryanodine receptor; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor calcium release channel; Cardiac muscle type ryanodine receptor; CCO; Central core disease of muscle; HBRR; hRYR 2; hRYR2; MHS; MHS1; Ryanodine receptor 1 (skeletal); Ryanodine receptor 1; Ryanodine receptor 2 (cardiac); Ryanodine receptor 2; Ryanodine receptor 3; Ryanodine receptor type1; RYDR; RYR 1; RYR 2; RYR 3; RYR; RYR1; RYR2; RYR3; Sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle type ryanodine receptor; SKRR; Type 1 like ryanodine receptor; VTSIP.

浓    度  1mg/1ml
规 格  0.2ml/200μg
抗体来源  Rabbit
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
产品类型  一抗  
研究领域  肿瘤 心血管 通道蛋白 细胞膜受体
蛋白分子量  predicted molecular weight: 566kDa 
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Ryanodine Receptor
亚    型  IgG
纯化方法   affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4


心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌产品应用  ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
产品介绍 The Ryanodine Receptor (RyR) is the channel responsible for calcium release from muscle cell Sarcoplasmic Reticulum (SR) and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains. The remainder of the protein, termed the "foot" region, is located in the cytoplasm between the transverse tubule and the SR. Mammalian RyR isoforms are the product of three different genes: RyR-1 is expressed predominantly in skeletal muscle and areas of the brain; RyR-2 is expressed predominantly in heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain; and RyR-3 is found in smooth muscle and the brain (striatum, thalamus and hippocampus). In non-mammalian vertebrates, the RyR isoforms are termed alpha, beta and cardiac which correlate loosely to the mammalian RyR-1, RyR-3 and RyR-2 isoforms respectively.
Function : Calcium channel that mediates the release of Ca(2+) fromthe sarcoplasmic reticulum into the cytoplasm and thereby plays akey role in triggering muscle contraction following depolarizationof T-tubules. Repeated very high-level exercise increases the openprobability of the channel and leads to Ca(2+) leaking into thecytoplasm. Can also mediate the release of Ca(2+) fromintracellular stores in neurons, and may thereby promote prolongedCa(2+) signaling in the brain. Required for normal embryonicdevelopment of muscle fibers and skeletal muscle. Required fornormal heart morphogenesis, skin development and ossificationduring embryogenesis (By similarity).
Subunit : Homotetramer. Can also form heterotetramers with RYR2.Interacts with CALM; CALM with bound calcium inhibits the RYR1channel activity. Interacts with S100A1. Interacts with FKBP1A;this stabilizes the closed conformation of the channel. Interactswith CACNA1S; interaction with CACNA1S is important for activationof the RYR1 channel. Interacts with CACNB1. Interacts with TRDN andASPH; these interactions stimulate RYR1 channel activity (Bysimilarity). Identified in a complex composed of RYR1, PDE4D, PKA,FKBP1A and protein phosphatase 1 (PP1). Repeated very high-levelexercise decreases interaction with PDE4D and protein phosphatase 1(PP1).
Subcellular Location : Sarcoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Tissue Specificity : Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.
Post-translational modifications : Channel activity is modulated by phosphorylation.Phosphorylation at Ser-2843 may increase channel activity. Repeatedvery high-level exercise increases phosphorylation at Ser-2843.[PTM] Activated by reversible S-nitrosylation. Repeated veryhigh-level exercise increases S-nitrosylation.
DISEASE : Malignant hyperthermia 1 (MHS1) [MIM:145600]: Autosomaldominant pharmacogenetic disorder of skeletal muscle and is one ofthe main causes of death due to anesthesia. In susceptible people,an MH episode can be triggered by all commonly used inhalationalanesthetics such as halothane and by depolarizing muscle relaxantssuch as succinylcholine. The clinical features of the myopathy arehyperthermia, accelerated muscle metabolism, contractures,metabolic acidosis, tachycardia and death, if not treated with thepostsynaptic muscle relaxant, dantrolene. Susceptibility to MH canbe determined with the 'in vitro' contracture test (IVCT):observing the magnitude of contractures induced in strips of muscletissue by caffeine alone and halothane alone. Patients with normalresponse are MH normal (MHN), those with abnormal response tocaffeine alone or halothane alone are MH equivocal (MHE(C) andMHE(H) respectively). Note=The disease is caused by mutationsaffecting the gene represented in this entry.
Central core disease of muscle (CCD) [MIM:117000]:Autosomal dominant congenital myopathy, but a severe autosomalrecessive form also exists. Both clinical and histologicalvariability is observed. Affected individuals typically displayhypotonia and proximal muscle weakness in infancy, leading to thedelay of motor milestones. The clinical course of the disorder isusually slow or nonprogressive in adulthood, and the severity ofthe symptoms may vary from normal to significant muscle weakness.Microscopic examination of CCD-affected skeletal muscle reveals apredominance of type I fibers containing amorphous-looking areas(cores) that do not stain with oxidative and phosphorylasehistochemical techniques. Note=The disease is caused by mutationsaffecting the gene represented in this entry.
Multiminicore disease with external ophthalmoplegia(MMDO) [MIM:255320]: Clinically heterogeneous neuromusculardisorder. General features include neonatal hypotonia, delayedmotor development, and generalized muscle weakness and amyotrophy,which may progress slowly or remain stable. Muscle biopsy showsmultiple, poorly circumscribed, short areas of sarcomeredisorganization and mitochondria depletion (areas termed minicores)in most muscle fibers. Typically, no dystrophic signs, such asmuscle fiber necrosis or regeneration or significant endomysialfibrosis, are present in multiminicore disease. Note=The disease iscaused by mutations affecting the gene represented in this entry.
Congenital myopathy with fiber-type disproportion (CFTD)[MIM:255310]: Genetically heterogeneous disorder in which there isrelative hypotrophy of type 1 muscle fibers compared to type 2fibers on skeletal muscle biopsy. However, these findings are notspecific and can be found in many different myopathic andneuropathic conditions. Note=The disease is caused by mutationsaffecting the gene represented in this entry.
Note=Defects in RYR1 may be a cause of Samaritanmyopathy, a congenital myopathy with benign course. Patientsdisplay severe hypotonia and respiratory distress at birth. Unlikeother congenital myopathies, the health status constantly improvesand patients are minimally affected at adulthood.
Similarity : Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.
Contains 3 B30.2/SPRY domains.
Contains 5 MIR domains.
Database links : UniProtKB/Swiss-Prot: P21817.3
Defects in the RYR2 gene are the cause of several heart diseases: 1) familial arrhythmogenic right ventricular dysplasia 2 (ARVD2), also known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2), 2) an autosomal dominant form of stress-induced polymorphic ventricular tachycardia (VTSIP), also known as catecholaminergic polymorphic ventricular tachycardia (CPVT) and 3) familial polymorphic ventricular tachycardia (FPVT). Ryanodine Receptor 2 contains several phosphorylatable sites. Specifically, Ser-2030 and Ser-2809 (or at Ser-2808 depending on the species) can be phosphoryated by protein kinase A (PKA) and Ser-2815 (or at Ser-2814 depending on the species) can be phosphorylated by CaMKII (Ca2+/calmodulin-dependent protein kinase II).


心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌具有全、新、优、品、好四大特点：
全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。
新：产品更新速度较快，基本上每周都有新产品出现。
优：产品质量好，投诉比较少。
好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务，可根据您科研的需求，满足您的需要，质量保证，价格合理。
一、标记流程
委托标记服务，请下载并详细填写《委托标记申请单》，待我公司标记室技术人员研究、确认后答复，并办理委托标记事宜。
二、各种标记物制备的收费标准（RMB） 
我们不但提供抗体和大分子蛋白的标记服务，还提供小分子多肽及小分子蛋白的各种标记服务，提供标记化合物的服务（此化合物必须适用于标记），价格另议。
一抗和二坑的区别：
第一抗体就是平常所说的抗体，即能和抗原特异性结合。
第二抗体是能和抗体结合的，即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体，二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说，抗原进入机体刺激机体免疫系统产生免疫应答，由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团，而且一抗可以至少结合两种其他基团（底物和二抗）。
一抗：可以特异结合底物，就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗：可以和一抗结合，并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），则不需要二抗。但这样成本很高，因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记，再来检测一抗。而一抗识别底物。这样，当一抗结合到底物上，就可以通过二抗检测出来。 

小鼠乙型肝炎表面抗原elisa试剂盒   小鼠乙型肝炎表面抗原试剂盒   规格型号：96T/48T   小鼠乙型肝炎表面抗原试剂盒，规格型号：96T/48T，来源：elisa试剂盒（进口分装），产品别名：小鼠乙型肝炎表面抗原试剂盒、小鼠乙型肝炎表面抗原elisa试剂盒   保存条件：2-8℃   保质期：6个月。
小鼠乙型肝炎e抗原elisa试剂盒   小鼠乙型肝炎e抗原试剂盒   规格型号：96T/48T   小鼠乙型肝炎e抗原试剂盒，规格型号：96T/48T，来源：elisa试剂盒（进口分装），产品别名：小鼠乙型肝炎e抗原试剂盒、小鼠乙型肝炎e抗原elisa试剂盒   保存条件：2-8℃   保质期：6个月。
小鼠乙型肝炎e抗体elisa试剂盒   小鼠乙型肝炎e抗体试剂盒   规格型号：96T/48T   小鼠乙型肝炎e抗体试剂盒，规格型号：96T/48T，来源：elisa试剂盒（进口分装），产品别名：小鼠乙型肝炎e抗体试剂盒、小鼠乙型肝炎e抗体elisa试剂盒   保存条件：2-8℃   保质期：6个月。
小鼠胰高血糖素样肽elisa试剂盒   小鼠胰高血糖素样肽试剂盒   规格型号：96T/48T   小鼠胰高血糖素样肽试剂盒，规格型号：96T/48T，来源：elisa试剂盒（进口分装），产品别名：小鼠胰高血糖素样肽试剂盒、小鼠胰高血糖素样肽elisa试剂盒   保存条件：2-8℃   保质期：6个月。
大鼠酶(CAT)ELISA试剂盒 ，英文名： CAT ELISA Kit
Rabbit acetylcholine receptor aibody (AChRab) ELISA Kit 兔乙酰胆碱受体抗体(AChRab)ELISA试剂盒
呼吸道合胞病毒(RSV)核酸检测试剂盒(PCR-荧光探针法) 48T
CLIAKitforMMP-9/GelatinaseB(Humanmaixmetalloproteinase9/GelatinaseB)ELISAKit人基质金属蛋白酶9/明胶酶B规格：48T/96T
体液基质金属蛋白酶(MMP)总活性荧光定量检测试剂盒20次
ELISAKitTXB2犬血栓素B2规格：48T/96T
小鼠胆固醇(CH)ELISA试剂盒 96T/48T 试剂盒 组装/原装
Human placeal lactogen (PL) ELISA Kit 人胎盘泌乳素(PL)ELISA试剂盒
Humahrombin-aithrombincomplex,TATELISAKit 人凝血酶抗凝血酶复合物(TAT)ELISA试剂盒 96T/48T 进口分装
Humanazurocidin,AZUELISA试剂盒人天青杀素(AZU)ELISA试剂盒规格：96T/48T
植物源性饲料大豆基因检测试剂盒20次
Humahrombin，TMELISAKit人凝血酶(TM)ELISA试剂盒规格：96T/48T
Anti-OAT4L/URAT1 /FITC 荧光素标记尿酸盐重吸收转运子1抗体IgGMulti-class antibodies规格： 0.2ml
Rabbit Anti-chicken IgG/HRP 辣根过氧化物酶标记兔抗鸡IgGMulti-class antibodies规格： 0.1ml
CD86抗体 Anti-CD86/B7-2 0.1ml
Goat Anti-Bovine IgG/PE-CY5 PE-CY5标记的羊抗IgG 0.1ml
Fibrillin 2 英文名称： 原纤维蛋白2抗体 0.2ml
Rhesus antibody Rh PLAU/UPA/Urokinase 尿激酶型纤溶酶原激活因子抗体 规格 0.1ml
Rabbit Anti-chicken IgG/HRP 辣根过氧化物酶标记兔抗鸡IgGMulti-class antibodies规格： 0.1ml
NKG2D(natural killer cell group 2D) NK细胞受体/自然杀伤细胞活化性受体Multi-class antibodies规格： 0.5mg
Anti-phospho-APP/ABPP(Tyr757) 化APP(Tyr757)淀粉样肽前体蛋白抗体Multi-class antibodies规格： 0.1ml
Rhesus antibody Rh Phospho-ATP1A1(Ser16) 化ATP酶蛋白a1抗体 规格 0.1ml
山羊抗狗 IgG(H+L)/HRP 0.1ml 美国Jackson公司分装
V.cholera Ogawa 英文名称： 01群稻叶型霍乱弧菌抗体 0.2ml
DMTF1 英文名称： 周期素D相互作用蛋白1抗体 0.2ml
Anti-phospho-APP/ABPP(Tyr757) 化APP(Tyr757)淀粉样肽前体蛋白抗体Multi-class antibodies规格： 0.1ml
心肌兰尼碱受体抗体（脑肌兰尼碱受体）品牌5HT2A Receptor 英文名称： 5-羟受体2A抗体 0.2ml
ETFA 英文名称： 电子转移黄素蛋白α抗体 0.2ml
血栓调节蛋白抗体 Anti-TM 0.2ml
Anti-TNFSF18/GITR Ligand/FITC 荧光素标记坏死因子配体超家族成员18抗体IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-JunB(Ser79) 化活化蛋白激酶B抗体 规格 0.1ml
BMP4(bone morphogenetic protein 4) 骨形态发生蛋白4(抗原)Multi-class antibodies规格： 0.5mg