GTP结合蛋白RAC1+RAC2抗体品牌

抗体名 ：GTP结合蛋白RAC1+RAC2抗体品牌

抗体英文名 ：Anti-RAC1+RAC2

靶点 ：详见说明书

浓度 ：1mg/1ml

应用范围 ：WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

宿主 ：详见说明书

供应商 ：上海博湖

库存 ：大量

级别 ：详见说明书

目录编号 ：详见说明书

抗原来源 ：Rabbit

保质期 ：详见说明书

适应物种 ：详见说明书

标记物 ：详见说明书

克隆性 ：多克隆

保存条件 ：Store at -20 °C

形态 ：大量

亚型 ：IgG

免疫原 ：KLH conjugated synthetic peptide derived from human RAC1/RAC2.

规格 ：0.2ml/200μg

中文名称  GTP结合蛋白RAC1+RAC2抗体品牌
英文名称  Anti-RAC1+RAC2
别    名  MIG5; p21 Rac1; Rac 1; Rac-1; p21 Rac2; PAK1; Ras like protein TC25; Ras related C3 botulinum toxin substrate 1; Ras related C3 botulinum toxin substrate 2; RAC1_HUMAN; RAC2_HUMAN.
GTP结合蛋白RAC1+RAC2抗体品牌是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品，产品品质卓越，价格实惠，多种规格供应，售后完善。

浓    度  1mg/1ml
规 格  0.1ml/100μg 0.2ml/200μg
抗体来源  Rabbit
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig
产品类型  一抗  
研究领域  肿瘤 细胞生物 信号转导 细胞凋亡 细胞粘附分子 G蛋白偶联受体
蛋白分子量  predicted molecular weight: 21kDa 
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human RAC1/RAC2.
亚    型  IgG
纯化方法   affinity purified by Protein A
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

GTP结合蛋白RAC1+RAC2抗体品牌产品应用  WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
产品介绍 The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Function : Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Subunit : Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with NISCH (By similarity). Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with PIP5K1A (By similarity).
Subcellular Location : Cell membrane. Melanosome. Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity : Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
Post-translational modifications : AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
Similarity : Belongs to the small GTPase superfamily. Rho family.
Database links : UniProtKB/Swiss-Prot: P63000.1
UniProtKB/Swiss-Prot: P15153.1


GTP结合蛋白RAC1+RAC2抗体品牌具有全、新、优、品、好四大特点：
全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。
新：产品更新速度较快，基本上每周都有新产品出现。
优：产品质量好，投诉比较少。
好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务，可根据您科研的需求，满足您的需要，质量保证，价格合理。
一、标记流程
委托标记服务，请下载并详细填写《委托标记申请单》，待我公司标记室技术人员研究、确认后答复，并办理委托标记事宜。
二、各种标记物制备的收费标准（RMB） 
我们不但提供抗体和大分子蛋白的标记服务，还提供小分子多肽及小分子蛋白的各种标记服务，提供标记化合物的服务（此化合物必须适用于标记），价格另议。
一抗和二坑的区别：
第一抗体就是平常所说的抗体，即能和抗原特异性结合。
第二抗体是能和抗体结合的，即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体，二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说，抗原进入机体刺激机体免疫系统产生免疫应答，由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团，而且一抗可以至少结合两种其他基团（底物和二抗）。
一抗：可以特异结合底物，就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗：可以和一抗结合，并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），则不需要二抗。但这样成本很高，因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记，再来检测一抗。而一抗识别底物。这样，当一抗结合到底物上，就可以通过二抗检测出来。 

血管紧张素转化酶   英文名称：   Angiotensin Conveing Enzyme   规格：   48T/96T   英文缩写：   ACE
膜联蛋白2   英文名称：   Annexin 2   规格：   48T/96T   英文缩写：   ANXA-2
骨碱性酶   英文名称：   bone alkaline phosphatase   规格：   48T/96T   英文缩写：   BALP
凋亡因子BAX   英文名称：   apoptogen BAX   规格：   48T/96T   英文缩写：   BAX
大鼠β内啡肽(β-EP)ELISA试剂盒 ，英文名： β-EP ELISA Kit
Rabbit immunoglobulin E (IgE) ELISA Kit 兔子免疫球蛋白E(IgE)ELISA试剂盒
ELISA 小鼠神经营养素4(mouse -4) 48T/96T 进口分装
CLIAKitforIL-12/PELISAKit大鼠白介素12规格：48T/96T
通用型马铃薯潜伏毒(RedLaSodaVirus;RLaSV/PotatolateVirus)基因检测试剂盒20次
ELISAKitVCAM-1/CD106大鼠血管内皮细胞粘附分子1规格：48T/96T
小鼠次核糖基转移酶1(HP1)ELISA试剂盒 ，英文名： HP1 ELISA Kit
人游离血红蛋白(f-Hb)ELISA检测试剂盒Humanfreehaemoglobin,f-HbELISAKit 96T/48T
大鼠卵清蛋白特异性IgE(OVA sIgE)免疫试剂盒 Rat ovalbumin specific IgE,OVA sIgE ELISA Kit
英文名称RatOsteocalcinELISAKit大鼠骨桥素(Osteocalcin)规格：96T/48T
酵母/ATP酶(H+/K+-ATPase)活性比色法定量检测试剂盒20次
ELISAKiLN人松弛肽/松弛素规格：48T/96T
Anti-P73 protein/FITC 荧光素标记P73抑制基因抗体IgGMulti-class antibodies规格： 0.2ml
Rabbit Anti-human IgG/Biotin 生物素化兔抗人IgGMulti-class antibodies规格： 0.1ml
CULLIN抗体 Anti-CULLIN/Cdc53/CUL/SCFCdc4 0.2ml
Rabbit Anti-mouse IgM/PE-Cy7 PE-Cy7标记的兔抗小鼠IgM 0.1ml
phospho-Filamin A (Ser1458) 英文名称： 化细丝蛋白A抗体 0.1ml
Rhesus antibody Rh Phospho-Wee1(Ser642) 化WEE1蛋白抗体 规格 0.1ml
Rabbit Anti-human IgG/Biotin 生物素化兔抗人IgGMulti-class antibodies规格： 0.1ml
integrin Beta1(ITG- Beta1/CD29) 粘附分子整合素β1抗原Multi-class antibodies规格： 0.5mg
Anti-ADRA2 ADRA2能受体2抗体Multi-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-CD19(Ser227) 化CD19抗体 规格 0.1ml
TMB双组分A+B液 AB液各500ml 用于ELISA
VGLL2 英文名称： 转录辅助因子退变样蛋白2抗体 0.2ml
Dnmt2 英文名称： DNA甲基转移酶2抗体 0.2ml
Anti-ADRA2 ADRA2能受体2抗体Multi-class antibodies规格： 0.2ml
GTP结合蛋白RAC1+RAC2抗体品牌SCG10 英文名称： 神经生长相关蛋白SCG10抗体 0.1ml
EDA 英文名称： 外胚层发育不良蛋白1抗体 0.2ml
X-连锁凋亡蛋白/性连锁凋亡抑制蛋白抗体 anti-XIAP 0.2ml
Anti-TSLC1/FITC 荧光素标记肺癌阻抑基因1抗体IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-IKK beta(Ser466) 化KB抑制蛋白激酶β抗体 规格 0.1ml
TrK A.B.C 神经生长因子的一种(抗原)Multi-class antibodies规格： 0.5mg