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抗体英文名 ：EGFR
库存 ：大量
抗原来源 ：其它
供应商 ：上海研卉生物科技有限公司
是否单克隆 ：多克隆
规格 ：10ug
【产品介绍】表皮生长因子受体 (epidermal growth fact o r recept o r , EGFR)是一种广泛分布于人体各组织细胞膜上的多功能糖蛋白，具有酪氨酶激酶活性，为HER/ErbB 家族的四个成员之一，故又名HER1 或ErbB-1。EGFR及其配体是细胞信号传导系统的一部分，受体一旦与表皮生长因子（EGF）结合可启动细胞核内的有关基因，从而促进细胞分裂增殖。 研究表明，EGFR 基因拷贝数增加或者过度表达，均能促进正常细胞的转化和恶性肿瘤的转移。EGFR 的信号传导网络在肿瘤的形成和发展过程中占了重要的地位。从1984 年EGFR基因被首次克隆，20 年来的研究显示，EGFR 是治疗肿瘤的一个很有前景的靶分子。Recombinant Human EGF Receptor (EGFR)
Product Details
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand-induced activation. EGFR can be activated by binding EGF, or at least six other structurally related protein ligands, including TGF-α, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade, which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble Human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.
Source: CHO cells
Synonyms: ErbB1
AA Sequence: LEEKKVCQGT SNKLTQLGTF EDHFLSLQRM FNNCEVVLGN LEITYVQRNY DLSFLKTIQE VAGYVLIALN TVERIPLENL QIIRGNMYYE NSYALAVLSN YDANKTGLKE LPMRNLQEIL HGAVRFSNNP ALCNVESIQW RDIVSSDFLS NMSMDFQNHL GSCQKCDPSC PNGSCWGAGE ENCQKLTKII CAQQCSGRCR GKSPSDCCHN QCAAGCTGPR ESDCLVCRKF RDEATCKDTC PPLMLYNPTT YQMDVNPEGK YSFGATCVKK CPRNYVVTDH GSCVRACGAD SYEMEEDGVR KCKKCEGPCR KVCNGIGIGE FKDSLSINAT NIKHFKNCTS ISGDLHILPV AFRGDSFTHT PPLDPQELDI LKTVKEITGF LLIQAWPENR TDLHAFENLE IIRGRTKQHG QFSLAVVSLN ITSLGLRSLK EISDGDVIIS GNKNLCYANT INWKKLFGTS GQKTKIISNR GENSCKATGQ VCHALCSPEG CWGPEPRDCV SCRNVSRGRE CVDKCNLLEG EPREFVENSE CIQCHPECLP QAMNITCTGR GPDNCIQCAH YIDGPHCVKT CPAGVMGENN TLVWKYADAG HVCHLCHPNC TYGCTGPGLE GCPTNGPKIP S
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Not available.
Calculated Molecular Weight: 68.6 kDa
Accession Number: P00533
Gene ID: 1956
| Kwon, Y W | Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications. | Stem Cells Translational Medicine; 8(3) pg236-246 | 0 Mar 2019 | 30474937 Show Usages |
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