泛素连接酶E3基因载体库，Ubiquitin E3 ligase

库存 ：10000

英文名 ：Ubiquitin E3 ligase

保质期 ：10年

供应商 ：深圳市上为生物科技有限公司

保存条件 ：-20℃

       泛素蛋白酶体途径是目前己知的所有真核生物体内具有高度选择性的最为重要的蛋白质降解途径。真核细胞中泛素化修饰后的靶蛋白可能被降解、可能被转移到细胞或细胞外的特定部位，也有可能导致靶蛋白的功能发生变化，这主要取决于靶蛋白所加的泛素链的结构，以及泛素链的长短。泛素连接酶E3决定靶蛋白的特异性识别，在泛素途径中具有重要的作用。泛素连接酶E3通过调控调节蛋白的泛素化过程参与细胞内的多种生理过程。所有的E3都具有连接靶蛋白和特定E2的能力。
       泛素连接酶E3 基因家族一共有600多个，本公司现已将接近200个基因克隆构建至慢病毒载体，新的基因持续克隆更新中。
      
     载体骨架是慢病毒载体：


E3 连接酶基因载体在293T细胞过表达后WB检测过表达效果展示：




表. 现已构建的泛素连接酶E3 基因载体列表。

Domain	No	基因编号	基因名称	基因别名	转录本编号
RING finger	1	LL.54467	ANKIB1	DKFZP434A0225,FLJ33123,KIAA1386	NM_019004
	2	LL.10425	ARIH2	ARI2,FLJ10938,FLJ33921,TRIAD1	NM_006321
	3	LL.329	BIRC2	API1,HIAP2,Hiap-2,MIHB,RNF48,cIAP1	NM_001166
	4	LL.330	BIRC3	AIP1,API2,CIAP2,HAIP1,HIAP1,MALT2,MIHC,RNF49	NM_001165 NM_182962
	5	LL.331	BIRC4	API3,ILP1,MIHA,XIAP,XLP2	NM_001167
	6	LL.112401	BIRC8	ILP-2,ILP2,hILP2	NM_033341
	7	LL.51283	BFAR	BAR,RNF47	NM_016561
	8	LL.648	BMI1	MGC12685,PCGF4,RNF51	NM_005180
	9	LL.8315	BRAP	BRAP2,IMP,RNF52	NM_006768
	10	LL.580	BARD1	-	NM_001282549
	11	LL.79872	CBLL1	FLJ23109,HAKAI,MGC163401,MGC163403,RNF188	NM_024814
	12	LL.4850	CNOT4	CLONE243,NOT4,NOT4H	NM_001190848
	13	LL.10668	CGRRF1	CGR19,RNF197	NM_006568
	14	LL.79596	RNF219/C13orf7	FLJ13449,FLJ25774	NM_024546
	15	LL.57820	CCNB1IP1	C14orf18,HEI10	NM_021178 NM_182849 NM_182851 NM_182852
	16	LL.2966	GTF2H2C_2		NM_001042490.4
	17	LL.255488	RNF144B/IBRDC2	KIAA0161,MGC71786,bA528A10.3,p53RFP	NM_182757
	18	LL.23609	MKRN2	HSPC070,RNF62	NM_014160
	19	LL.55167	MSL2L1	FLJ10546,KIAA1585,MSL-2,RNF184	NM_001145417.1
	20	LL.4194	MDM4	DKFZp781B1423,MDMX,MGC132766,MRP1	NM_002393
	21	LL.54708	'MARCH5	FLJ20445,MARCH-V,RNF153, MITOL	NM_017824
	22	LL.4331	MNAT1	MAT1,RNF66	NM_002431
	23	LL.79594	MUL1/C1orf166	FLJ12875,RP11-401M16.2, C1orf166	NM_024544
	24	LL.29116	MYLIP	MIR	NM_013262
	25	LL.197370	NSMCE1	NSE1	NM_145080
	26	LL.5071	PARK2	AR-JP,LPRS2,PDJ,PRKN	NM_004562 NM_013987 NM_013988
	27	LL.5193	PEX12	-	NM_000286
	28		PEX2		NM_000318.2
	29	LL.84759	PCGF1	FLJ43754,MGC10882,NSPC1,RNF3A-2,RNF68	NM_032673
	30	LL.10336	PCGF3	DONG1,FLJ36550,FLJ43813,RNF3,RNF3A	NM_001317836.1
	31	LL.84333	PCGF5	MGC16202,RNF159	NM_001256549.1
	32	LL.9867	PJA2	KIAA0438,Neurodap1,RNF131	NM_014819
	33	LL.51136	RNFT1/LOC51136	MGC111090	NM_016125
	34	LL.442247	RFPL4B	RNF211	NM_001013734
	35	LL.89970	RSPRY1	KIAA1972	NM_001305163.1
	36		RFWD3		NM_018124.3
	37		RNF6		NM_005977.3
	38	LL.26994	RNF11	CGI-123,MGC51169,SID1669	NM_014372.4
	39	LL.168433	RNF133	MGC27072	NM_139175
	40	LL.51444	RNF138	HSD-4,MGC8758,NARF,STRIN	NM_001191324.1
	41	LL.9604	RNF14	ARA54,FLJ26004,HFB30,HRIHFB2038	NM_001201365.1
	42	LL.81847	RNF146	DKFZP434O1427,RP3-351K20.1,dJ351K20.1	NM_001242844.1
	43	LL.378925	RNF148	MGC35222	NM_198085
	44	LL.220441	RNF152	FLJ39176,MGC138161	NM_173557.2
	45	LL.494470	RNF165	-	NM_001256758.1
	46	LL.26001	RNF167	5730408C10Rik,DKFZP566H073,LP2254	NM_001320356.1
	47	LL.138065	RNF183	FLJ31197,MGC4734	NM_145051.3
	48	LL.91445	RNF185	FLJ38628	NM_152267.3
	49	LL.54546	RNF186	FLJ20225,RP11-91K11.1	NM_019062.1
	50		RNF2		NM_007212.3
	51	LL.257160	RNF214	DKFZp547C195	NM_001077239.1
	52		RNF214		NM_207343.3
	53	LL.11237	RNF24	G1L	NM_001134337.2
	54	LL.64320	RNF25	AO7,FLJ13906	NM_022453.2
	55		RNF32		NM_030936.3
	56	LL.80196	RNF34	FLJ21786,RFI,RIF,RIFF	NM_001256858.1
	57	LL.6047	RNF4	RES4-26,SNURF	NM_001185009.2
	58	LL.10193	RNF41	MGC45228,NRDP1,SBBI03	NM_001242826.1
	59	LL.9978	RBX1	BA554C12.1,MGC13357,MGC1481,RNF75,ROC1	NM_014248.3
	60	LL.6477	SIAH1	HUMSIAH,Siah-1,Siah-1a,hSIAH1	NM_001006610.1
	61	LL.7188	TRAF5	MGC:39780,RNF84	NM_001033910.2
	62	LL.7189	TRAF6	MGC:3310,RNF85	NM_004620.3
	63		TRIM13		NM_001007278.2
	64		TRIM22		NM_001199573.1
65	LL.373	TRIM23	ARD1,ARFD1,RNF46	NM_001656.3
66		TRIM38		NM_006355.4
67	LL.166655	TRIM60	FLJ35882,MGC119325,RNF129,RNF33	NM_001258025.1
68		CBLL2		NM_152577.3
U box	69	LL.23759	PPIL2	CYC4,CYP60,FLJ39930	NM_014337 NM_148175 NM_148176
	70	LL.27339	PRPF19	NMP200,PRP19,PSO4,SNEV,UBOX4,hPSO4	NM_014502
	71	LL.10273	STUB1	CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1	NM_005861.3
F box	72	LL.8945	BTRC	FBW1A,FBXW1A,FWD1,bTrCP,betaTrCP	NM_003939 NM_033637
	73	LL.54850	FBXL12	FLJ20188,Fbl12	NM_017703.2
	74	LL.84961	FBXL20	Fbl2,Fbl20,MGC15482	NM_032875.2
	75	LL.26224	FBXL3	FBL3,FBL3A,FBXL3A	NM_012158.2
	76		FBXL4		NM_001278716.1
	77		FBXL5		NM_012161.3
	78	LL.23291	FBXW11	BTRC2,BTRCP2,FBW1B,FBXW1B,Fbw11,Hos	NM_033644.2
	79		FBXW7		NM_001013415.1
	80	LL.26273	FBXO3	DKFZp564B092,FBA,FBX3	NM_012175.3
	81		FBXO30		NM_032145.4
	82	LL.55030	FBXO34	CGI-301,FLJ20725,Fbx34,MGC126434,MGC126435	NM_017943.3
	83		FBXO38		NM_001271723.1
SOCS box	84		ASB7		NM_024708.3
	85		ASB8		NM_024095.4
	86		ASB9		NM_024087.2
	87		SOCS3		NM_003955.4
	88		SOCS4		NM_080867.2
	89		SOCS6		NM_004232.3
	90		WSB1		NM_015626.9
	91		WSB2		NM_018639.4
BTB	92	LL.80325	ABTB1	BPOZ,EF1ABP,MGC20585,PP2259	NM_032548 NM_172027 NM_172028
	93		BTBD10		NM_001297741.1
	94		BTBD3		NM_001282550.1
	95		BACH1		NM_001186.3
	96		CCIN		NM_005893.2
	97		IVNS1ABP		NM_006469.4
	98		KCTD1		NM_198991.3
	99		KCTD14		NM_001282406.1
	100		KCTD21		NM_001029859.2
	101		KCTD4		NM_198404.2
	102		KCTD6		NM_153331.3
	103		KCTD7		NM_001167961.2
	104		KBTBD2		NM_015483.2
	105		KBTBD3		NM_001330359.1
	106		KLHL20		NM_014458.3
	107		RCBTB2		NM_001268.3
	108		RHOBTB3		NM_014899.3
	109		SPOP		NM_001007226.1
	110		ZBTB24		NM_001164313.1
	111		ZBTB25		NM_006977.4
	112		ZBTB26		NM_020924.3
	113		ZBTB37		NM_001122770.2
	114		ZBTB39		NM_014830.2
	115		ZBTB6		NM_006626.5
	116		ZBTB8A		NM_001040441.2
	117		ZNF131		NM_001297548.2
	118		ZBTB18		NM_006352.4
	119		ZBTB49		NM_145291.3
HECT	120	LL.8916	HERC3	KIAA0032	NM_014606
	121		HECTD2		NM_173497.3
	122		UBE3A		NM_000462.4
	123		ITCH		NM_031483.6
	124		G2E3		NM_017769.4
	125		SMURF2		NM_022739.3
	126		UBE3C		NM_014671.2
	127		WWP1		NM_007013.3
ZnF_A20	128	LL.27342	RABGEF1	FLJ32302 RABEX5 rabex-5	NM_014504
	129		ZFAND6		NM_019006.3
	130	LL.868	CBLB	FLJ36865,RNF56	NM_170662
	131		FANCL		NM_018062.3
	132	LL.51132	RNF12	MGC15161,NY-REN-43,RLIM	NM_016120.3
	133	LL.79845	RNF122	FLJ12526,MGC126622	NM_024787
	134	LL.50862	RNF141	MGC8715,ZFP26,ZNF230	NM_016422.3
	135	LL.25897	RNF19	DKFZp566B1346,DORFIN	NM_001280539.1
	136
	137	LL.79102	RNF26	MGC2642	NM_032015.4
	138		TRAIP		NM_005879.2
	139	LL.6737	TRIM21	RNF81,RO52,SSA,SSA1	NM_003141.3
	140		TRIM34		NM_001003827.1
	141	LL.286827	TRIM59	MRF1,RNF104,TRIM57,TSBF1	NM_173084.2
	142	LL.27072	VPS41	HVPS41,HVSP41,hVps41p	NM_014396.3
	143		DZIP3		NM_014648.3
	144		FBXW2		NM_012164.3
	145	LL.26269	FBXO8	DC10,FBS,FBX8	NM_012180.2
	146		ASB3		NM_016115.4
	147		ASB6		NM_017873.3
	148		ENC1		NM_003633.3
	149		KCNA10		NM_005549.2
	150		KCNA6		NM_002235.3
	151		ZBTB43		NM_014007.3
	152		ZBTB5		NM_014872.2
	153		ZBTB9		NM_152735.3
	154		ZBTB14		NM_001143823.2
	155		MARCH7		NM_022826.3
	156	LL.55120	FANCL	FLJ10335,PHF9,POG	NM_018062
	157	LL.222484	LNX2	FLJ12933,FLJ23932,FLJ38000,MGC46315,PDZRN1	NM_153371
	158	LL.29116	MYLIP	MIR	NM_013262
	159	LL.197370	NSMCE1	NSE1	NM_145080
	160	LL.5828	PXMP3	PAF-1,PAF1,PEX2,PMP3,PMP35,RNF72	NM_000318 NM_001079867
	161	LL.56852	RAD18	RNF73	NM_020165
	162		RNF182		NM_001165032.1
	163	LL.10293	TRAIP	RNF206,TRIP	NM_005879.2
	164	LL.85363	TRIM5	RNF88,TRIM5alpha	NM_033034.2
	165		FBXO5		NM_001142522.2
	166	LL.81790	RNF170	DKFZP564A022,FLJ38306	NM_001160223.1
	167	LL.51255	RNF181	HSPC238	NM_016494.3
	168	LL.221687	RNF182	FLJ40772,MGC33993	NM_001165032.1
	169	LL.6048	RNF5	RING5,RMA1	NM_006913.3
	170	LL.9616	RNF7	CKBBP1,ROC2,SAG	NM_014245.4
	171		SOCS5		NM_014011.4
	172		WSB1		NM_015626.9
	173		BTBD3		NM_001282550.1
	174		KCNS3		NM_002252.4
	175		KCNA1		NM_000217.2
	176		SPOP		NM_001007226.1
	177		AREL1		NM_001039479.1
	178		ZFAND5		NM_006007.3

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