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供应商 :上海联迈生物工程有限公司
库存 :大量
靶点 :详见说明书
级别 :1
目录编号 :LM-11178R-FITC
克隆性 :多克隆
抗原来源 :Rabbit
保质期 :1年
抗体英文名 :Anti-Signal Peptide Peptidase/FITC
抗体名 :Anti-Signal Peptide Peptidase/FITC
标记物 :FITC标记
宿主 :Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
适应物种 :Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
免疫原 :详见说明书
亚型 :IGg
形态 :粉末、液体、冻干粉
应用范围 :ICC=1:50-200 IF=1:50-200
浓度 :1mg/ml
保存条件 :-20 °C
规格 :100ul
FITC标记的信号肽肽酶SPP抗体英文名称 | Anti-Signal Peptide Peptidase/FITC |
中文名称 | FITC标记的信号肽肽酶SPP抗体 |
别 名 | Histocompatibility (minor) 13; HM 13; HM13; HM13_HUMAN; IMP 1; IMP-1; IMP1; IMPAS; IMPAS-1; Intramembrane Protease 1; Intramembrane protease; Minor Histocompatibility 13; Minor histocompatibility antigen 13; Minor histocompatibility antigen H13; MSTP086; Presenilin like protein 3; Presenilin-like protein 3; PSENL 3; PSENL3; PSL 3; PSL3; Signal peptide peptidase; Signal peptide peptidase beta; SPP; dJ324O17.1; H13; hIMP1; hIMP1 protein. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 免疫学 神经生物学 信号转导 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 42kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Signal Peptide Peptidase |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The endoplasmic reticulum exerts a quality control over newly synthesized proteins and a variety of components have been implicated in the specific recognition of aberrant or misfolded polypeptides. Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. SPP is required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides, and may play a role in graft rejection. It also may be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Function: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Isoform 4: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. Post-translational modifications: N-glycosylated. Similarity: Belongs to the peptidase A22B family. Database links: Entrez Gene: 81502 Human Omim: 607106 Human SwissProt: Q8TCT9 Human Unigene: 373741 Human Unigene: 444601 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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