WNK4 Peptide

保存条件 ：Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.

保质期 ：参照说明书可保存1-2年

英文名 ：WNK4 Peptide

库存 ：一定量库存

供应商 ：华拓生物

CAS号 ：见详细说明

规格 ：0.1 mg

产品名称：	WNK4 Peptide
产品链接：	http://www.abbiotec.com/peptides/wnk4-peptide
货号：	350572
规格：	0.1 mg
产品描述：	Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII).
序列：	The synthetic peptide used to raise the antibody Cat. No. 250912 is selected from a sequence within the N-term region of mouse WNK4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
分子式：	C64H89N13O21
分子量：	1375.6 g/mol
纯度：	Purity > 80% by HPLC
别名：	WNK4; Ser/Thr-protein kinase WNK4; Serine/threonine-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine–deficient 4
形态：	Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
溶解方法：	Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
保存方法：	Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.