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保存条件 :Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
库存 :货期:1-2天
供应商 :MedChemExpress LLC
规格 :10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
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BMS-794833
CAS No. : 1174046-72-0
MCE 国际站:BMS-794833
产品活性:BMS-794833 是 VEGFR2 和 Met 的抑制剂,来自专利WO2009094417, 化合物实例1,IC50 值分别为15 和 1.7 nM。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:c-Met/HGFR | VEGFR
In Vitro: BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM.
In Vivo: BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days.
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