大鼠基质金属蛋白酶-13

库存 ：100

供应商 ：北京博奥森生物技术有限公司

检测限 ：5 μg/L

检测方法 ：ELISA双抗体夹心法

应用 ：ELISA

适应物种 ：Rat

标记物 ：HRP

样本 ：cell culture supernates, serum, and plasma.

线性范围：10 - 300 μg/L.Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene.It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain PDB: 1PEX​. Although the actual mechanism has not been described, the hemopexin domain participates in collagen degradation, the catalytic domain alone being particularly inefficient in collagen degradation. During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis.