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抗体名 :CD4免疫组化抗体,
抗体英文名 :CD4 Antibody Rabbit Monoclonal
应用范围 :IHC
宿主 : Rabbit Monoclonal
供应商 :上海研卉生物科技有限公司
库存 :大量
适应物种 :人
保质期 :一年
是否单克隆 :0
保存条件 :低温
规格 :3ml
CD4免疫组化抗体,Ready-to-useApplication
|
IHC |
---|---|
Primary Accession | P01730 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Isotype | IgG |
Clone Names | 458G4A1 |
Gene ID | 920 |
---|---|
Gene Name | CD4 |
Other Names | T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4 |
Dilution | IHC~~Ready-to-use |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T- helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. |
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Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum |
Tissue Location | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
上海研卉生物科技有限公司
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入驻年限:10年