CD4免疫组化抗体,Ready-to-use

CD4免疫组化抗体,Ready-to-use

价格: ¥1813

品牌:abgent

货号:AD80285

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抗体名 :CD4免疫组化抗体,

抗体英文名 :CD4 Antibody Rabbit Monoclonal

应用范围 :IHC

宿主 : Rabbit Monoclonal

供应商 :上海研卉生物科技有限公司

库存 :大量

适应物种 :

保质期 :一年

是否单克隆 :0

保存条件 :低温

规格 :3ml

CD4免疫组化抗体,Ready-to-use Product info
Application
IHC
Primary Accession P01730
Reactivity Human
Host Rabbit
Clonality Monoclonal
Isotype IgG
Clone Names 458G4A1
Additional info
Gene ID 920
Gene Name CD4
Other Names T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4
Dilution IHC~~Ready-to-use
Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions CD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T- helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum
Tissue Location Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

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入驻年限:10年

联系人:李先生

地址:上海

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