MSX1 MSH同源蛋白1样蛋白抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

目录编号 ：LM-8512R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：MSX1

抗体名 ：MSH同源蛋白1样蛋白抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Dog, Cow,

免疫原 ：KLH conjugated synthetic peptide derived from human MSX1:151-297/297

亚型 ：IgG

形态 ：Lyophilized or Liquid

应用范围 ：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg /Test IF=1:50-200 （石蜡切片需做抗原修复）

浓度 ：1mg/ml

保存条件 ：Store at -20 °C

规格 ：50ul  100ul  200ul

MSX1 MSH同源蛋白1样蛋白抗体

英文名称	MSX1
中文名称	MSH同源蛋白1样蛋白抗体
别    名	Msh homeobox 1 like protein; Homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX 1; Homeobox protein MSX-1; Homeobox protein MSX1; Homeobox, msh like 1; Homeobox, msh-like 1; HOX 7; Hox 7.1; Hox-7; HOX7; Hox7.1; HYD 1; HYD1; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); Msh; msh homeo box 1; msh homeo box homolog 1; Msh homeobox 1; Msh homeobox 1-like protein; msh homeobox homolog 1 (Drosophila); msh homeobox homolog 1; MSH, Drosophila, Homolog of, 1; MSX 1; MSX1; MSX1_HUMAN; Muscle segment homeobox; Muscle segment homeobox, Drosophila, Homolog of, 1; OFC5; STHAG1.
	Specific References  (1)     |     bs-8512R has been referenced in 1 publications. [IF=1.85] Mu, Hailong, et al. "The function of Msx1 gene in promoting meiosis of dairy goat male germline stem cells (mGSCs)." Cell Biochemistry and Function (2013).  Goat.   PubMed:24123057
规格价格	50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书	50ul  100ul  200ul
研究领域	细胞生物  免疫学  神经生物学  信号转导  干细胞
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Cow,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg /Test IF=1:50-200 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	31kDa
细胞定位	细胞核
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human MSX1:151-297/297
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Function: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Subcellular Location: Nucleus Tissue Specificity: Expressed in the developing nail bed mesenchyme. Post-translational modifications: Sumoylated by PIAS1, desumoylated by SENP1 (By similarity). DISEASE: Defects in MSX1 are the cause of tooth agenesis selective type 1 (STHAG1) [MIM:106600]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Tooth agenesis selective type 1 can be associated with orofacial cleft in some patients.  Note=MSX1 is deleted in some patients with Wolf-Hirschhorn syndrome (WHS). WHS results from sub-telomeric deletions in the short arm of chromosome 4.  Defects in MSX1 are the cause of Witkop syndrome (WITS) [MIM:189500]. WITS is a form of ectodermal dyslasia also called tooth-and-nail syndrome or dysplasia of nails with hypodontia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Witkop syndrome is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.  Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.  Similarity: Belongs to the Msh homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P28360 Gene ID: 4487 Database links: Entrez Gene: 4487 Human Entrez Gene: 17701 Mouse Entrez Gene: 81710 Rat Entrez Gene: 692067 Rhesus monkey Omim: 142983 Human SwissProt: Q2VL88 Chimpanzee SwissProt: O02786 Cow SwissProt: P28360 Human SwissProt: P13297 Mouse SwissProt: Q2VL87 Rhesus monkey Unigene: 424414 Human Unigene: 256509 Mouse Unigene: 18117 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Sample:  Utreus (Mouse) Lysate at 40 ug Hela Cell (Human) Lysate at 40 ug Siha Cell (Human) Lysate at 40 ug A673 Cell (Human) Lysate at 40 ug Primary: Anti- MSX1 (bs-8512R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩?? for 20 min;  Incubation: Anti-MSX1 Polyclonal Antibody, Unconjugated(bs-8512R) 1:200, overnight at 4掳C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Positive control: Hela cells Concebtration: 5μg/10^6 cells Incubation conditions: Avoid light , 30 minutes on the ice.