phospho-Kv2.1(Tyr128)磷酸化钾通道蛋白DRK1抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

目录编号 ：LM-5535R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：phospho-Kv2.1(Tyr128)

抗体名 ：磷酸化钾通道蛋白DRK1抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

免疫原 ：KLH conjugated Synthesised phosphopeptide derived from human Kv21 around the phosphorylation site of Tyr128:DEI(p-Y)LE

亚型 ：IgG

形态 ：Lyophilized or Liquid

应用范围 ：ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

浓度 ：1mg/ml

保存条件 ：Store at -20 °C

规格 ：100ul

phospho-Kv2.1(Tyr128)磷酸化钾通道蛋白DRK1抗体

英文名称	phospho-Kv2.1(Tyr128)
中文名称	磷酸化钾通道蛋白DRK1抗体
别    名	Kv2.1 (phospho Y128); p-Kv2.1 (phospho Y128); Kv2.1(phospho Y128); Delayed rectifier potassium channel 1; Delayed rectifier potassium channel Kv2.1; DRK 1; DRK1; h DRK1 K(+) channel; h-DRK1; hDRK 1; hDRK1; KCB 1; KCB1; KCNB1; KCNB1_HUMAN; KV2.1; Potassium channel protein DRK1; Potassium voltage gated channel shab related subfamily member 1; Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1.
规格价格	100ul/1580元 购买        大包装/询价
说 明 书	100ul
产品类型	磷酸化抗体
研究领域	肿瘤  免疫学  激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	96kDa
细胞定位	细胞膜
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated Synthesised phosphopeptide derived from human Kv21 around the phosphorylation site of Tyr128:DEI(p-Y)LE
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq]. Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.  Subunit: Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein.  Post-translational modifications: Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively (By similarity). Similarity: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily. SWISS: Q14721 Gene ID: 3745 Database links: Entrez Gene: 3745 Human Entrez Gene: 16500 Mouse Entrez Gene: 25736 Rat Omim: 600397 Human SwissProt: Q14721 Human SwissProt: Q03717 Mouse SwissProt: P15387 Rat Unigene: 84244 Human Unigene: 387390 Mouse Unigene: 26724 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Tissue/cell: Rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-Kv2’1 Polyclonal Antibody, Unconjugated(bs-5535R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining