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适应物种 :Natural and recombinant Human ANG-2
检测限 :156 pg/mL- 10000pg/mL
供应商 :上海研卉生物科技有限公司
库存 :4W
规格 :96T
血管紧张素ANG-2 ELISA试剂盒Human ANG-2 Pre-Coated ELISA Kit
Product Details
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich “coiled coil” N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. The BioGems Human ANG-2 Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure ANG-2 with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for ANG-2. It contains NS0-expressed recombinant ANG-2. The detection antibody is a biotinylated goat polyclonal antibody specific for ANG-2. The kit is analytically validated with ready to use reagents.
Sandwich ELISA:
Assay Type:
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Solid Phase Sandwich ELISA: 96-Well Strip Plate
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Sensitivity:
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<10 pg/ml
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Range:
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156 pg/mL- 10000pg/mL
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Specificity:
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Natural and recombinant Human ANG-2
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Uniprot:
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O15123
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Interference:
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No detectable cross-reactivity with other relevant proteins
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上海研卉生物科技有限公司
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入驻年限:10年